A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
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Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesAutistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionPositive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortexSynthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophreniaRealistic expectations of prepulse inhibition in translational models for schizophrenia research.Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptorsCentrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in ratsNeurobiological Insights from mGlu Receptor Allosteric Modulation.Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signalingBiased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR CurrentsPharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.The antipsychotic potential of muscarinic allosteric modulationNew therapeutic targets for mood disordersBipolar disorder: candidate drug targets.N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinAllosteric modulation of metabotropic glutamate receptors.Targeting glutamate synapses in schizophreniaDiscovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsLoss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeSynthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm.Antipsychotic-induced gene regulation in multiple brain regions.Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.mGluR7's lucky number.
P2860
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P2860
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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name
A novel selective positive all ...... ects in rat behavioral models.
@ast
A novel selective positive all ...... ects in rat behavioral models.
@en
A novel selective positive all ...... ects in rat behavioral models.
@nl
type
label
A novel selective positive all ...... ects in rat behavioral models.
@ast
A novel selective positive all ...... ects in rat behavioral models.
@en
A novel selective positive all ...... ects in rat behavioral models.
@nl
prefLabel
A novel selective positive all ...... ects in rat behavioral models.
@ast
A novel selective positive all ...... ects in rat behavioral models.
@en
A novel selective positive all ...... ects in rat behavioral models.
@nl
P2093
P356
P1476
A novel selective positive all ...... ects in rat behavioral models.
@en
P2093
Cyrille Sur
David D Wisnoski
David L Williams
Denise J Bickel
Douglas J Pettibone
Gene G Kinney
Julie A O'Brien
Mark E Duggan
Marlene A Jacobson
Maryann Burno
P304
P356
10.1124/JPET.104.079244
P407
P577
2004-12-17T00:00:00Z