The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats.
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SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in ratsFuture pharmacological treatments for substance use disordersUsing glutamate homeostasis as a target for treating addictive disordersDesign and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in ratsGlutamatergic substrates of drug addiction and alcoholismMetabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotinemGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in ratsNegative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic WindowThe "stop" and "go" of nicotine dependence: role of GABA and glutamateMetabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant DependenceGlutamatergic transmission in drug reward: implications for drug addictionAnhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophreniaStructure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonistHomers regulate drug-induced neuroplasticity: implications for addictionPartial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addictionCue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seekingOperant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intakeThe mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.Open label smoking cessation with varenicline is associated with decreased glutamate levels and functional changes in anterior cingulate cortex: preliminary findings.Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopyCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats.Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system.Acute effects of nicotine amplify accumbal neural responses during nicotine-taking behavior and nicotine-paired environmental cues.Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in ratsFenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans.Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues.Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response.Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine.A role for glutamate in subjective response to smoking and its action on inhibitory control.Beta-lactam antibiotic decreases acquisition of and motivation to respond for cocaine, but not sweet food, in C57Bl/6 mice.The metabotropic glutamate 2/3 receptor agonist LY379268 blocked nicotine-induced increases in nucleus accumbens shell dopamine only in the presence of a nicotine-associated context in rats.mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in ratsMetabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats
P2860
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P2860
The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@ast
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@en
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@nl
type
label
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@ast
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@en
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@nl
prefLabel
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@ast
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@en
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@nl
P1433
P1476
The metabotropic glutamate rec ...... ine, cocaine and food in rats.
@en
P2093
Athina Markou
Neil E Paterson
P2888
P304
P356
10.1007/S00213-004-2070-9
P577
2004-12-24T00:00:00Z
P6179
1038866107