A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.
about
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham StudySIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stressCrystal structures of human SIRT3 displaying substrate-induced conformational changesSirtuins deacetylate and activate mammalian acetyl-CoA synthetasesSIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stressSirtuins and Cancer: Role in the Epithelial-Mesenchymal TransitionHuman longevity: Genetics or Lifestyle? It takes two to tangoThe Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary FibrosisRedox regulation of FoxO transcription factorsForever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegenerationSirtuin 1 and sirtuin 3: physiological modulators of metabolismSIRT3 regulates progression and development of diseases of aging.Sirtuins in hematological aging and malignancyRegulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and agingMaintaining good hearing: calorie restriction, Sirt3, and glutathioneFunction of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative diseaseSirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesisBiochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylationEnergy intake and exercise as determinants of brain health and vulnerability to injury and diseaseMammalian sirtuins: biological insights and disease relevanceSirtuins in mammals: insights into their biological functionModulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)".Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscleExogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathwaySIRT3 substrate specificity determined by peptide arrays and machine learning.The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.Sirtuins: guardians of mammalian healthspan.Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.Respected Sir(2): magic target for diabetesRecent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies.Loss of Sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction.Fasting mitigates immediate hypersensitivity: a pivotal role of endogenous D-beta-hydroxybutyrate.Human longevity and 11p15.5: a study in 1321 centenariansMitochondrial-nuclear epistasis: implications for human aging and longevity.Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjectsDecreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress.Between destiny and disease: genetics and molecular pathways of human central nervous system aging
P2860
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P2860
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A novel VNTR enhancer within t ...... with survival at oldest ages.
@ast
A novel VNTR enhancer within t ...... with survival at oldest ages.
@en
A novel VNTR enhancer within t ...... with survival at oldest ages.
@nl
type
label
A novel VNTR enhancer within t ...... with survival at oldest ages.
@ast
A novel VNTR enhancer within t ...... with survival at oldest ages.
@en
A novel VNTR enhancer within t ...... with survival at oldest ages.
@nl
prefLabel
A novel VNTR enhancer within t ...... with survival at oldest ages.
@ast
A novel VNTR enhancer within t ...... with survival at oldest ages.
@en
A novel VNTR enhancer within t ...... with survival at oldest ages.
@nl
P2093
P50
P1433
P1476
A novel VNTR enhancer within t ...... d with survival at oldest ages
@en
P2093
Claudio Franceschi
Emidio Feraco
Giovanna De Benedictis
Giuseppe Passarino
Giuseppina Covello
Paola Cavalcante
Valentina Greco
Vincenzo Mari
P304
P356
10.1016/J.YGENO.2004.11.003
P577
2005-02-01T00:00:00Z