Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. - Wikidata - wikimedia - TriplyDB

Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.

Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.

http://www.wikidata.org/entity/Q34398455

about

Epithelial cell polarity: a major gatekeeper against cancer?Cell polarity signaling in the plasticity of cancer cell invasiveness A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia Asymmetric cell division of stem and progenitor cells during homeostasis and cancer The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration.Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.Multiple strategies of oxygen supply in Drosophila malignancies identify tracheogenesis as a novel cancer hallmark (A)symmetric stem cell replication and cancer Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium.Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM.Expression of Hugl-1 is strongly reduced in malignant melanoma.Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.Expression of polarity genes in human cancer.Modeling tumor invasion and metastasis in Drosophila Genomic alterations in rectal tumors and response to neoadjuvant chemoradiotherapy: an exploratory study.Brush border myosin Ia has tumor suppressor activity in the intestine.Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex.Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth.MiR-652-3p is upregulated in non-small cell lung cancer and promotes proliferation and metastasis by directly targeting Lgl1.PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1.Par complex in cancer: a regulator of normal cell polarity joins the dark side.Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module.Human papillomaviruses, cervical cancer and cell polarity.Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA.Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer.Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.Drosophila lethal giant larvae neoplastic mutant as a genetic tool for cancer modeling.Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.Lessons from development: A role for asymmetric stem cell division in cancer.Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.Pathobiology of colorectal cancer hepatic metastases with an emphasis on prognostic factors.Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment.Regulation of self-renewal in normal and cancer stem cells.Epithelial cell polarity: what flies can teach us about cancer.The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

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Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.

http://www.wikidata.org/entity/Q34398455

description

2005 nî lūn-bûn

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2005 թվականի ապրիլին հրատարակված գիտական հոդված

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2005年の論文

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Reduced expression of Hugl-1, ...... gression of colorectal cancer.

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Carl C Schimanski

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Dennis Strand

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Stephan C Schäfer

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Susanne Strand

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P2860

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2

Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma.

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

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