Induction of somatic mutation in a human B cell line in vitro.
about
Two novel human and mouse DNA polymerases of the polX familySomatic hypermutation introduces insertions and deletions into immunoglobulin V genesRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceIdentification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression dataTranscription, beta-like DNA polymerases and hypermutationIn vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Genetic diversity of the allodeterminant alr2 in Hydractinia symbiolongicarpusWhat role for AID: mutator, or assembler of the immunoglobulin mutasome?Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genesKnown components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasDNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell linesChronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndromeSequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells.Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.Timing matters: error-prone gap filling and translesion synthesis in immunoglobulin gene hypermutationChromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instabilityTumor necrosis factor-alpha and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells.DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.Human B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported by CD40 ligand.IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells.Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes.Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomasDoes AID need another aid?Somatic hypermutation of antibody genes: a hot spot warms up.Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase.Somatic mutations of synaptic cadherin (CNR family) transcripts in the nervous system.Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes.Isolation of a high-affinity Bet v 1-specific IgG-derived ScFv from a subject vaccinated with hypoallergenic Bet v 1 fragments.The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.Monocytoid B cells: an enigmatic B cell subset showing evidence of extrafollicular immunoglobulin gene somatic hypermutation.Hypothesis: biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation.
P2860
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P2860
Induction of somatic mutation in a human B cell line in vitro.
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Induction of somatic mutation in a human B cell line in vitro.
@ast
Induction of somatic mutation in a human B cell line in vitro.
@en
Induction of somatic mutation in a human B cell line in vitro.
@nl
type
label
Induction of somatic mutation in a human B cell line in vitro.
@ast
Induction of somatic mutation in a human B cell line in vitro.
@en
Induction of somatic mutation in a human B cell line in vitro.
@nl
prefLabel
Induction of somatic mutation in a human B cell line in vitro.
@ast
Induction of somatic mutation in a human B cell line in vitro.
@en
Induction of somatic mutation in a human B cell line in vitro.
@nl
P2093
P1433
P1476
Induction of somatic mutation in a human B cell line in vitro.
@en
P2093
Blanchard D
Denépoux S
Lebecque S
Razanajaona D
P356
10.1016/S1074-7613(00)80240-X
P407
P577
1997-01-01T00:00:00Z