The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.
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Molecular basis for activation of G protein-coupled receptor kinasesmTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideStructure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationSelectivity of docking sites in MAPK kinasesStructures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activationAbscisic acid perception and signaling: structural mechanisms and applicationsPKA: lessons learned after twenty yearsAssembly of allosteric macromolecular switches: lessons from PKADesign principles underpinning the regulatory diversity of protein kinasesPKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform DiversityContribution of Non-catalytic Core Residues to Activity and Regulation in Protein Kinase AStructure of dystrophia myotonica protein kinaseComparative surface geometry of the protein kinase familyStructural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionActivation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase DomainA Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma VirulenceLocalization and quaternary structure of the PKA RI holoenzymeParoxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial ContractilityStructural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinasesStructure and Allostery of the PKA RII Tetrameric HoloenzymeThe discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug designMolecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA AptamerCrystal structure of human CDC7 kinase in complex with its activator DBF4Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain constructDynamics-Driven Allostery in Protein KinasesAtomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor KinasesProtein kinase C: poised to signalMycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assemblyComputational insights into the inhibitory mechanism of human AKT1 by an orally active inhibitor, MK-2206Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailThe mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CCoordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.Protein kinases: evolution of dynamic regulatory proteinsComputational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesMolecular assembly of rhodopsin with G protein-coupled receptor kinases.Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screeningGlobal consequences of activation loop phosphorylation on protein kinase A.
P2860
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P2860
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The hallmark of AGC kinase fun ...... cis-acting regulatory module.
@ast
The hallmark of AGC kinase fun ...... cis-acting regulatory module.
@en
type
label
The hallmark of AGC kinase fun ...... cis-acting regulatory module.
@ast
The hallmark of AGC kinase fun ...... cis-acting regulatory module.
@en
prefLabel
The hallmark of AGC kinase fun ...... cis-acting regulatory module.
@ast
The hallmark of AGC kinase fun ...... cis-acting regulatory module.
@en
P2093
P2860
P356
P1476
The hallmark of AGC kinase fun ...... cis-acting regulatory module.
@en
P2093
Andrew F Neuwald
Natarajan Kannan
Nina Haste
Susan S Taylor
P2860
P304
P356
10.1073/PNAS.0610251104
P407
P577
2007-01-16T00:00:00Z