FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
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The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanismComprehensive Map of Molecules Implicated in ObesityThe Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise.Changes in gene expression associated with FTO overexpression in mice.Modification effects of genetic polymorphisms in FTO, IL-6, and HSPD1 on the associations of diabetes with breast cancer risk and survival.Early hypothalamic FTO overexpression in response to maternal obesity--potential contribution to postweaning hyperphagia.Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner.Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humansFat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2.Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese.Does FTO have a paradoxical effect in fetal life?Dietary Fat Modifies the Effects of FTO Genotype on Changes in Insulin Sensitivity.FTO Inhibits Insulin Secretion and Promotes NF-κB Activation through Positively Regulating ROS Production in Pancreatic β cells.FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies.Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patientsMouse Maternal High-Fat Intake Dynamically Programmed mRNA m⁶A Modifications in Adipose and Skeletal Muscle Tissues in Offspring.Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays.AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosineSystematic review: association of polycystic ovary syndrome with metabolic syndrome and non-alcoholic fatty liver disease.Skeletal muscle reactive oxygen species: a target of good cop/bad cop for exercise and disease.Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility.FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver.Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis.Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease.The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity.Variation in sequence and expression of the avian FTO, and association with glucose metabolism, body weight, fatness and body composition in chickens.Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice.Genes associated with Type 2 Diabetes and vascular complications.Hepatic expression of FTO and fatty acid metabolic genes changes in response to lipopolysaccharide with alterations in m6A modification of relevant mRNAs in the chicken.Transcriptional regulation of metabolism in disease: From transcription factors to epigenetics.
P2860
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P2860
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@ast
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@en
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@nl
type
label
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@ast
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@en
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@nl
prefLabel
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@ast
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@en
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@nl
P2093
P2860
P50
P921
P356
P1433
P1476
FTO is increased in muscle dur ...... ces mitochondrial dysfunction.
@en
P2093
Amélie Bravard
Emmanuel Disse
Emmanuelle Meugnier
Julien Vouillarmet
Martine Laville
Nöel Peretti
Sandra Pesenti
P2860
P304
P356
10.2337/DB10-0281
P407
P577
2010-10-13T00:00:00Z