CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease.

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q34450215

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Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms Metabolic reserve as a determinant of cognitive aging Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease Mice Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression.Spines, plasticity, and cognition in Alzheimer's model mice Epigenetic Modifications, Alcoholic Brain and Potential Drug Targets The role of mTOR signaling in Alzheimer disease microRNA-181a is involved in insulin-like growth factor-1-mediated regulation of the transcription factor CREB1 MicroRNAs in addiction: adaptation's middlemen?mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.Epigenetic memory: the Lamarckian brain Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3β, neurotrophin-3 and CREB signaling.Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.The cellular distribution and Ser262 phosphorylation of tau protein are regulated by BDNF in vitro.Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease.Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60 Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.Regulation of brain-derived neurotrophic factor expression in neurons.Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways.Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.Epigenetic mechanisms in neurological disease Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in rats Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant?

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P2860

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q34450215

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

CBP gene transfer increases BD ...... model of Alzheimer's disease.

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CBP gene transfer increases BD ...... model of Alzheimer's disease.

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CBP gene transfer increases BD ...... model of Alzheimer's disease.

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type

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CBP gene transfer increases BD ...... model of Alzheimer's disease.

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CBP gene transfer increases BD ...... model of Alzheimer's disease.

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CBP gene transfer increases BD ...... model of Alzheimer's disease.

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prefLabel

CBP gene transfer increases BD ...... model of Alzheimer's disease.

@ast

CBP gene transfer increases BD ...... model of Alzheimer's disease.

@en

CBP gene transfer increases BD ...... model of Alzheimer's disease.

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PNAS.1012851108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

CBP gene transfer increases BD ...... model of Alzheimer's disease.

@en

P2093

Alex F Bokov

http://www.w3.org/2001/XMLSchema#string

Antonella Caccamo

http://www.w3.org/2001/XMLSchema#string

Monica A Maldonado

http://www.w3.org/2001/XMLSchema#string

Salvatore Oddo

http://www.w3.org/2001/XMLSchema#string

Smita Majumder

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P2860

Alzheimer's Disease

Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

CBP/p300 in cell growth, transformation, and development

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

CREB-binding protein and p300 in transcriptional regulation

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Regulation of NMDA receptor trafficking by amyloid-beta

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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22687-22692

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scholarly article

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10.1073/PNAS.1012851108

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52

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107

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2010-12-13T00:00:00Z

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49675536

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21149712

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Alzheimer's disease

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3012497

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