about
The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregationMechanism of prion propagation: amyloid growth occurs by monomer additionDisease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact StructureAggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assaysProbing protein aggregation using discrete molecular dynamicsExtended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein.The Protein Structure Context of PolyQ RegionsSynchrotron infrared microspectroscopy detecting the evolution of Huntington's disease neuropathology and suggesting unique correlates of dysfunction in white versus gray brain matter.SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregatesShort G-rich oligonucleotides as a potential therapeutic for Huntington's DiseaseProteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.Prion protein insertional mutations increase aggregation propensity but not fiber stability.Differential hydrophobicity drives self-assembly in Huntington's disease.Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy.Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.A compact beta model of huntingtin toxicity.Cytosolic chaperonin protects folding intermediates of Gbeta from aggregation by recognizing hydrophobic beta-strandsStructural insights into functional and pathological amyloid.Neurodegenerative disorders: Parkinson's disease and Huntington's diseaseBreaking symmetry in protein dimers: designs and functions.A polymer physics perspective on driving forces and mechanisms for protein aggregationCould peripartum antibiotics have delayed health consequences for the infant?Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy.Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxiaComprehensive experimental fitness landscape and evolutionary network for small RNA.Polyglutamine diseases: where does toxicity come from? what is toxicity? where are we going?Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?Nuclear polyglutamine-containing protein aggregates as active proteolytic centers.Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila.Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln.Amyloid nanospheres from polyglutamine rich peptides: assemblage through an intermolecular salt bridge interaction.E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity.Atomistic mechanisms of huntingtin N-terminal fragment insertion on a phospholipid bilayer revealed by molecular dynamics simulations.Biodegradable delivery system containing a peptide inhibitor of polyglutamine aggregation: a step toward therapeutic development in Huntington's disease.HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells.GSK3beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis.Folding of polyglutamine chains.Ataxin-3 is subject to autolytic cleavage.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Polyglutamine fibrillogenesis: the pathway unfolds
@ast
Polyglutamine fibrillogenesis: the pathway unfolds
@en
Polyglutamine fibrillogenesis: the pathway unfolds
@nl
type
label
Polyglutamine fibrillogenesis: the pathway unfolds
@ast
Polyglutamine fibrillogenesis: the pathway unfolds
@en
Polyglutamine fibrillogenesis: the pathway unfolds
@nl
prefLabel
Polyglutamine fibrillogenesis: the pathway unfolds
@ast
Polyglutamine fibrillogenesis: the pathway unfolds
@en
Polyglutamine fibrillogenesis: the pathway unfolds
@nl
P2860
P50
P356
P1476
Polyglutamine fibrillogenesis: the pathway unfolds
@en
P2093
Michelle A Poirier
P2860
P356
10.1073/PNAS.0237018100
P407
P577
2002-12-30T00:00:00Z