Werner protein protects nonproliferating cells from oxidative DNA damage - Wikidata - wikimedia - TriplyDB

Werner protein protects nonproliferating cells from oxidative DNA damage

Werner protein protects nonproliferating cells from oxidative DNA damage

http://www.wikidata.org/entity/Q34467601

about

Human RECQL5 participates in the removal of endogenous DNA damage Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1 Roles of Werner syndrome protein in protection of genome integrity Human premature aging, DNA repair and RecQ helicases The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.The role of RecQ helicases in non-homologous end-joining DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells Acetylation regulates WRN catalytic activities and affects base excision DNA repair.Oxidative stress and antioxidant response in fibroblasts from Werner and atypical Werner syndromes.Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases.Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome protein DNA repair deficiency in neurodegeneration.Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells.Roles of the Werner syndrome RecQ helicase in DNA replication.The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice.WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging.From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Helicases as prospective targets for anti-cancer therapy.The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases.Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts.Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.

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Werner protein protects nonproliferating cells from oxidative DNA damage

http://www.wikidata.org/entity/Q34467601

description

2005 nî lūn-bûn

@nan

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Werner protein protects nonproliferating cells from oxidative DNA damage

@ast

Werner protein protects nonproliferating cells from oxidative DNA damage

@en

Werner protein protects nonproliferating cells from oxidative DNA damage

@nl

type

label

Werner protein protects nonproliferating cells from oxidative DNA damage

@ast

Werner protein protects nonproliferating cells from oxidative DNA damage

@en

Werner protein protects nonproliferating cells from oxidative DNA damage

@nl

prefLabel

Werner protein protects nonproliferating cells from oxidative DNA damage

@ast

Werner protein protects nonproliferating cells from oxidative DNA damage

@en

Werner protein protects nonproliferating cells from oxidative DNA damage

@nl

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P2860

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Q34467601-FCA59A0B-6F3F-4A9D-AA2E-167DFBE666F7

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P356

MCB.25.23.10492-10506.2005

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Molecular and Cellular Biology

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Werner protein protects nonproliferating cells from oxidative DNA damage

@en

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Abdelhakim Ben Nasr

http://www.w3.org/2001/XMLSchema#string

Allon Canaan

http://www.w3.org/2001/XMLSchema#string

Anna M Szekely

http://www.w3.org/2001/XMLSchema#string

Astrid Nümann

http://www.w3.org/2001/XMLSchema#string

Elisabeth Manasanch

http://www.w3.org/2001/XMLSchema#string

Franziska Bleichert

http://www.w3.org/2001/XMLSchema#string

Sherman M Weissman

http://www.w3.org/2001/XMLSchema#string

Stephen Van Komen

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

Regulation and localization of the Bloom syndrome protein in response to DNA damage

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

Asymmetry of DNA replication fork progression in Werner's syndrome

The Bloom's syndrome gene product is homologous to RecQ helicases

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

p53-mediated apoptosis is attenuated in Werner syndrome cells

Mutator phenotype of Werner syndrome is characterized by extensive deletions

Werner protein recruits DNA polymerase delta to the nucleolus

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10492-10506

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scholarly article

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10.1128/MCB.25.23.10492-10506.2005

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P433

23

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25

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2005-12-01T00:00:00Z

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16287861

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1291253

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