Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
about
Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleusDisruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disabilityInvestigating synapse formation and function using human pluripotent stem cell-derived neuronsA small molecule that binds Hedgehog and blocks its signaling in human cellsInduction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays.Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signalingA novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcriptionA novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalusDevelopment-on-chip: in vitro neural tube patterning with a microfluidic deviceHedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish.Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic HedgehogMyeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells.Controlling destiny through chemistry: small-molecule regulators of cell fate.Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere culturesGi proteins mediate activation of the canonical hedgehog pathway in the myocardium.Proteomic assessment of a cell model of spinal muscular atrophyIdentification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicineSmall-molecule modulators of the Sonic Hedgehog signaling pathway.Yeast-based assay identifies novel Shh/Gli target genes in vertebrate developmentChemical biology in stem cell research.The role of small molecules in musculoskeletal regeneration.Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development.Cooperative activity of noggin and gremlin 1 in axial skeleton development.Hedgehog activity controls opening of the primary mouth.Drugging Hedgehog: signaling the pathway to translation.Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1Discovery of small-molecule modulators of the Sonic Hedgehog pathway.Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.Lateral transport of Smoothened from the plasma membrane to the membrane of the ciliumActivation of heterotrimeric G proteins by Smoothened.Hedgehog pathway agonism: therapeutic potential and small-molecule development.Regeneration and repair of the exocrine pancreas.Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.The hedgehog/Gli signaling paradigm in prostate cancerThe formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cellsPtch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell linesHedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.
P2860
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P2860
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@ast
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@en
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@nl
type
label
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@ast
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@en
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@nl
prefLabel
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@ast
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@en
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
@nl
P356
P1476
Purmorphamine activates the Hedgehog pathway by targeting Smoothened
@en
P2093
Surajit Sinha
P2888
P356
10.1038/NCHEMBIO753
P577
2005-11-20T00:00:00Z