Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. - Wikidata - wikimedia - TriplyDB

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

http://www.wikidata.org/entity/Q34555453

about

Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy Cucurbitacins - a promising target for cancer therapy Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease Cucurbitacins - An insight into medicinal leads from nature Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation NF-κB and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma.Role of STAT3 in cancer metastasis and translational advances.Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway.Stat3-positive tumor cells contribute to vessels neoformation in primary central nervous system lymphoma JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila.Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes.Downregulation of signal transducer and activator of transcription 3 by sorafenib: a novel mechanism for hepatocellular carcinoma therapy.The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells.Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer.6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo Targeting karyotypic complexity and chromosomal instability of cancer cells.Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network.Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.Multifocal angiostatic therapy: an update.Interleukin-6 in aging and chronic disease: a magnificent pathway Regulation of AKT gene expression by cisplatin A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo Antitumor effects of Dasatinib on laryngeal squamous cell carcinoma in vivo and in vitro.Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress.Leptin increases adult hippocampal neurogenesis in vivo and in vitro.Genomic dissection of the cytokine-controlled STAT5 signaling network in liver LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model.Growth inhibitory effect of Cucurbitacin E on breast cancer cells.

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P2860

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

http://www.wikidata.org/entity/Q34555453

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@ast

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@en

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@nl

type

label

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@ast

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@en

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@nl

prefLabel

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@ast

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@en

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@nl

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Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

@en

P2093

Domenico Coppola

http://www.w3.org/2001/XMLSchema#string

Jiazhi Sun

http://www.w3.org/2001/XMLSchema#string

Michelle A Blaskovich

http://www.w3.org/2001/XMLSchema#string

Richard Jove

http://www.w3.org/2001/XMLSchema#string

Sandra K Livingston

http://www.w3.org/2001/XMLSchema#string

Saïd M Sebti

http://www.w3.org/2001/XMLSchema#string

P2860

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

How cells respond to interferons

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

Inhibitors of cytokine signal transduction.

Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.

The state of the STATs: recent developments in the study of signal transduction to the nucleus.

P2888

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3236-3245

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10.1038/SJ.ONC.1208470

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20

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24

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2005-05-01T00:00:00Z

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7997607

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1049947113

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15735720

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