A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
about
Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cellsLoss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expressionNF-κB and STAT3 in glioblastoma: therapeutic targets coming of ageThe role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyondTumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategiesIdentification of a core miRNA-pathway regulatory network in glioma by therapeutically targeting miR-181d, miR-21, miR-23b, β-Catenin, CBP, and STAT3Chemical probes that competitively and selectively inhibit Stat3 activationBrevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cellsIdentification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validationA novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.STAT6 expression in glioblastoma promotes invasive growthEGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance.A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cellsRegulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapyStat3-positive tumor cells contribute to vessels neoformation in primary central nervous system lymphomaSorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3Hypoxia potentiates glioma-mediated immunosuppressionTranscription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications.The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma.Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance.Inhibition of STAT3 activity re-activates anti-tumor immunity but fails to restore the immunogenicity of tumor cells in a B-cell lymphoma modelJAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma.Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathwayShort hairpin RNA-mediated fibronectin knockdown delays tumor growth in a mouse glioma model.Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation.Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair.Intratumoral mediated immunosuppression is prognostic in genetically engineered murine models of glioma and correlates to immunotherapeutic responses.WP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axisBenzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling.2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinaseIncreased STAT1 signaling in endocrine-resistant breast cancer.Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivoGlioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells.A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.Molecular heterogeneity in a patient-derived glioblastoma xenoline is regulated by different cancer stem cell populations.
P2860
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P2860
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A novel inhibitor of the STAT3 ...... ells both in vitro and in vivo
@ast
A novel inhibitor of the STAT3 ...... ells both in vitro and in vivo
@en
type
label
A novel inhibitor of the STAT3 ...... ells both in vitro and in vivo
@ast
A novel inhibitor of the STAT3 ...... ells both in vitro and in vivo
@en
prefLabel
A novel inhibitor of the STAT3 ...... ells both in vitro and in vivo
@ast
A novel inhibitor of the STAT3 ...... ells both in vitro and in vivo
@en
P2093
P2860
P921
P356
P1433
P1476
A novel inhibitor of the STAT3 ...... ells both in vitro and in vivo
@en
P2093
S Szymanski
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210031
P407
P577
2006-10-16T00:00:00Z