Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase
about
Matriptase zymogen supports epithelial development, homeostasis and regenerationMembrane-anchored serine proteases in vertebrate cell and developmental biologyThe protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.Detection of active matriptase using a biotinylated chloromethyl ketone peptideMatriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in LactationActivity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cellsNatural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Early detection biomarkers for ovarian cancer.Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptaseProstasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.The matriptase-prostasin proteolytic cascade in epithelial development and pathology.Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality.The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.Strong expression association between matriptase and its substrate prostasin in breast cancer.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase.
P2860
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P2860
Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Transport via the transcytotic ...... as a substrate for matriptase
@ast
Transport via the transcytotic ...... as a substrate for matriptase
@en
Transport via the transcytotic ...... as a substrate for matriptase
@nl
type
label
Transport via the transcytotic ...... as a substrate for matriptase
@ast
Transport via the transcytotic ...... as a substrate for matriptase
@en
Transport via the transcytotic ...... as a substrate for matriptase
@nl
prefLabel
Transport via the transcytotic ...... as a substrate for matriptase
@ast
Transport via the transcytotic ...... as a substrate for matriptase
@en
Transport via the transcytotic ...... as a substrate for matriptase
@nl
P2093
P2860
P356
P1476
Transport via the transcytotic ...... as a substrate for matriptase
@en
P2093
Chen-Yong Lin
Jette Bornholdt
Joanna Selzer-Plon
Lotte K Vogel
Sine Godiksen
Stine Friis
P2860
P304
P356
10.1074/JBC.M110.186874
P407
P577
2010-12-10T00:00:00Z