Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response.
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Strategies for treatment in Alexander diseaseAlexander diseaseGFAP and its role in Alexander diseaseDysfunctions of neuronal and glial intermediate filaments in diseaseAstrocytes are central in the pathomechanisms of vanishing white matterGenetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survivalThe origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander diseaseAstrocytic TDP-43 pathology in Alexander diseaseDrug screening to identify suppressors of GFAP expressionOligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.Knockdown of MLC1 in primary astrocytes causes cell vacuolation: a MLC disease cell model.Characterization of a panel of monoclonal antibodies recognizing specific epitopes on GFAP.Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways.Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease.Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasiaInhibition of Na+/H+ exchanger isoform 1 is neuroprotective in neonatal hypoxic ischemic brain injury.Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease modelThe myelin mutants as models to study myelin repair in the leukodystrophies.Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.The impact of glial activation in the aging brainNeurological diseases as primary gliopathies: a reassessment of neurocentrismAlexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytesElevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease.CSF and Blood Levels of GFAP in Alexander DiseaseBeneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.Nitric oxide mediates glial-induced neurodegeneration in Alexander diseaseAn In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease.GFAP expression as an indicator of disease severity in mouse models of Alexander disease.Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander diseaseFunctional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinicDual transgenic reporter mice as a tool for monitoring expression of glial fibrillary acidic protein.Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander DiseaseCaspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation.Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander diseaseThe role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP.Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility.Emerging role of autophagy in pediatric neurodegenerative and neurometabolic diseases.ASTROCYTES: EMERGING STARS IN LEUKODYSTROPHY PATHOGENESIS.Astrocyte pathology in Alexander disease causes a marked inflammatory environment.Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker.
P2860
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P2860
Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Alexander disease-associated g ...... white matter stress response.
@ast
Alexander disease-associated g ...... white matter stress response.
@en
Alexander disease-associated g ...... white matter stress response.
@nl
type
label
Alexander disease-associated g ...... white matter stress response.
@ast
Alexander disease-associated g ...... white matter stress response.
@en
Alexander disease-associated g ...... white matter stress response.
@nl
prefLabel
Alexander disease-associated g ...... white matter stress response.
@ast
Alexander disease-associated g ...... white matter stress response.
@en
Alexander disease-associated g ...... white matter stress response.
@nl
P2093
P1476
Alexander disease-associated g ...... a white matter stress response
@en
P2093
Albee Messing
Jolien X Connor
Tracy L Hagemann
P304
11162-11173
P356
10.1523/JNEUROSCI.3260-06.2006
P407
P577
2006-10-01T00:00:00Z