Short telomeres limit tumor progression in vivo by inducing senescence.
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Short telomeres initiate telomere recombination in primary and tumor cellsRegulation of glucose metabolism by p53: emerging new roles for the tumor suppressorThe short and long telomere syndromes: paired paradigms for molecular medicineTherapeutic targeting of replicative immortalityRetinoids induce cellular senescence in breast cancer cells by RAR-β dependent and independent pathways: Potential clinical implications (Review)Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivoLysosome-mediated processing of chromatin in senescence.Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations.Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.Amelioration of streptozotocin-induced diabetes in mice with cells derived from human marrow stromal cells.A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.Syndromes of telomere shorteningEscape of U251 glioma cells from temozolomide-induced senescence was modulated by CDK1/survivin signalingA sequence-dependent exonuclease activity from Tetrahymena thermophila.A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging.PRL-3 promotes telomere deprotection and chromosomal instability.Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.The cytotoxic ribonuclease onconase targets RNA interference (siRNA).Multiple Mechanisms Contribute To Telomere Maintenance.The essence of senescence.TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in miceRegulation of senescence in cancer and aging.Functional characterization of the TERRA transcriptome at damaged telomeres.HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.Novel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence.Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceBranched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein.The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses.Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk.PinX1: a sought-after major tumor suppressor at human chromosome 8p23Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.Novel ARF/p53-independent senescence pathways in cancer repression.Cellular senescence and organismal aging.Telomeric G-quadruplexes are a substrate and site of localization for human telomeraseDysfunction of the TP53 tumor suppressor gene in lymphoid malignancies.
P2860
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P2860
Short telomeres limit tumor progression in vivo by inducing senescence.
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Short telomeres limit tumor progression in vivo by inducing senescence.
@ast
Short telomeres limit tumor progression in vivo by inducing senescence.
@en
Short telomeres limit tumor progression in vivo by inducing senescence.
@nl
type
label
Short telomeres limit tumor progression in vivo by inducing senescence.
@ast
Short telomeres limit tumor progression in vivo by inducing senescence.
@en
Short telomeres limit tumor progression in vivo by inducing senescence.
@nl
prefLabel
Short telomeres limit tumor progression in vivo by inducing senescence.
@ast
Short telomeres limit tumor progression in vivo by inducing senescence.
@en
Short telomeres limit tumor progression in vivo by inducing senescence.
@nl
P2860
P1433
P1476
Short telomeres limit tumor progression in vivo by inducing senescence.
@en
P2093
David M Feldser
P2860
P304
P356
10.1016/J.CCR.2007.02.026
P577
2007-04-12T00:00:00Z