Raf proteins and cancer: B-Raf is identified as a mutational target.
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Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceConstitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosisPreponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastasesAbsence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanomaThe structure and function of NKAIN2-a candidate tumor suppressorCurrent and future trials of targeted therapies in cutaneous melanomaRecurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapyThe N-terminal domain of ERK1 accounts for the functional differences with ERK2BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implicationsDopamine promotes striatal neuronal apoptotic death via ERK signaling cascadesRegulation and role of Raf-1/B-Raf heterodimerization.A critical function for B-Raf at multiple stages of myelopoiesisRegistered Report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivationAn Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase InhibitorsA Combined Pharmacophore Modeling, 3D QSAR and Virtual Screening Studies on Imidazopyridines as B-Raf InhibitorsIdentification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK bindingMixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsProliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitorsAutoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritisPersonalized medicine: the future is not what it used to be.Prognostic factors of papillary and follicular carcinomas in Japan based on data of kuma hospital.BRAF V600E maintains proliferation, transformation, and tumorigenicity of BRAF-mutant papillary thyroid cancer cellsDysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunitiesV600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitorsBRAF inactivation drives aneuploidy by deregulating CRAFMutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma.Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinaseHalorhodopsin pumps Cl- and bacteriorhodopsin pumps protons by a common mechanism that uses conserved electrostatic interactions.Recent advances in molecular diagnosis of thyroid cancer.Can systems biology understand pathway activation? Gene expression signatures as surrogate markers for understanding the complexity of pathway activation.Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin.cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression.Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth controlBRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectumInhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)Conferring specificity on the ubiquitous Raf/MEK signalling pathway.The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
P2860
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P2860
Raf proteins and cancer: B-Raf is identified as a mutational target.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Raf proteins and cancer: B-Raf is identified as a mutational target.
@ast
Raf proteins and cancer: B-Raf is identified as a mutational target.
@en
Raf proteins and cancer: B-Raf is identified as a mutational target.
@nl
type
label
Raf proteins and cancer: B-Raf is identified as a mutational target.
@ast
Raf proteins and cancer: B-Raf is identified as a mutational target.
@en
Raf proteins and cancer: B-Raf is identified as a mutational target.
@nl
prefLabel
Raf proteins and cancer: B-Raf is identified as a mutational target.
@ast
Raf proteins and cancer: B-Raf is identified as a mutational target.
@en
Raf proteins and cancer: B-Raf is identified as a mutational target.
@nl
P1476
Raf proteins and cancer: B-Raf is identified as a mutational target.
@en
P2093
Catrin A Pritchard
Kathryn E Mercer
P407
P577
2003-06-01T00:00:00Z