In vivo demonstration that alpha-synuclein oligomers are toxic. - Wikidata - wikimedia - TriplyDB

In vivo demonstration that alpha-synuclein oligomers are toxic.

In vivo demonstration that alpha-synuclein oligomers are toxic.

http://www.wikidata.org/entity/Q34652122

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Structures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein protein Alzheimer mechanisms and therapeutic strategies The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity Mapping out the multistage fibrillation of glucagon Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain Definition of a molecular pathway mediating α-synuclein neurotoxicity Versatile Structures of α-Synuclein Sumoylation in Synaptic Function and Dysfunction Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α -Synuclein Levels in Parkinson's Disease: A Meta-Analysis Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders Targeting heat shock proteins to modulate α-synuclein toxicity Molecular chaperones and co-chaperones in Parkinson disease Exploring the accessible conformations of N-terminal acetylated α-synuclein Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity Protein degradation pathways in Parkinson's disease: curse or blessing Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis Sequestration of a β-hairpin for control of α-synuclein aggregation More than a Rumor Spreads in Parkinson's Disease Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students Seeking a mechanism for the toxicity of oligomeric α-synuclein Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers.

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In vivo demonstration that alpha-synuclein oligomers are toxic.

http://www.wikidata.org/entity/Q34652122

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

In vivo demonstration that alpha-synuclein oligomers are toxic.

@ast

In vivo demonstration that alpha-synuclein oligomers are toxic.

@en

In vivo demonstration that alpha-synuclein oligomers are toxic.

@nl

type

label

In vivo demonstration that alpha-synuclein oligomers are toxic.

@ast

In vivo demonstration that alpha-synuclein oligomers are toxic.

@en

In vivo demonstration that alpha-synuclein oligomers are toxic.

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prefLabel

In vivo demonstration that alpha-synuclein oligomers are toxic.

@ast

In vivo demonstration that alpha-synuclein oligomers are toxic.

@en

In vivo demonstration that alpha-synuclein oligomers are toxic.

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PNAS.1100976108

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Proceedings of the National Academy of Sciences of the United States of America

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In vivo demonstration that alpha-synuclein oligomers are toxic.

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Antonella Consiglio

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Christos Tzitzilonis

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Claudia Hetzer

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Emiley Pham

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Fred H Gage

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Helena Mira

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Roberto Jappelli

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Roland Riek

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Sebastian Jessberger

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Silvia Campioni

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P2860

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

alpha-Synuclein locus triplication causes Parkinson's disease

Alpha-synuclein and neurodegenerative diseases

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Ageing and Parkinson's disease: substantia nigra regional selectivity

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

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108

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Eliezer Masliah

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49839728

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21325059

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