Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction
about
Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complexNrf2 and Notch Signaling in Lung Cancer: Near the CrossroadNrf2 Is an Attractive Therapeutic Target for Retinal DiseasesDiscovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsThe clinical potential of influencing Nrf2 signaling in degenerative and immunological disordersThe status of Nrf2-based therapeutics: current perspectives and future prospectsThe Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK PathwayProtein-protein interactions as drug targets.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.Non-electrophilic modulators of the canonical Keap1/Nrf2 pathwayActivation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor.NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivativesS6K2: The Neglected S6 Kinase Family Member.Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening.The emerging role of Nrf2 in mitochondrial functionSynthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives.Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases.Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides.Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation.Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction InhibitorsMetabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species.Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cellsDevelopment of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction.Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate.Synthesis of Novel Nitrogen-Containing Heterocycle Bromophenols and Their Interaction with Keap1 Protein by Molecular Docking.Identification of Non-Electrophilic Nrf2 Activators from Approved Drugs.Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a reviewThe mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding
P2860
Q27689053-9ED3EB1F-FCF6-441C-A6C9-61E38C033D3CQ28066915-702D5862-4FCC-4B58-9115-D6C2AF06AE1BQ28077181-416BAF25-4DFD-47D8-8F20-BD4A8112176CQ28085561-02A95CC8-AD6B-432C-B189-C291DF688A89Q28395641-D75827DA-1E56-4550-80B3-DA09E18F5FA8Q28818264-55AAC8AC-1931-4FAD-BB2C-CAEBFB734B35Q33659621-A2CCB82F-C3F3-4898-8257-009900F4A20EQ34043797-48B196B4-8780-48C9-91A0-580C46621B2FQ34974952-27C42A7B-A0B0-416F-A8DA-960868E48DE5Q35738960-F7F02463-970D-4930-8D59-C89CE762E83FQ35814106-EB1FD0E0-BAD0-4F78-8D48-FAEAF3E344BAQ35824701-9474BD87-545C-4BDD-BA2C-F42356AA8C4AQ35981250-DCFC381D-382D-4B10-9D26-878E9D2512F5Q36144939-F5E31C2E-119D-49FD-92AE-8E2C384FE967Q36277241-66E6079A-DCDD-485F-A80D-325CF3272D3EQ36463474-B56E74E6-30D4-4BC9-B0D2-F21D986A5653Q37170555-C2820C38-C353-44F9-A477-4344121514F5Q38125196-73B7D180-5DCD-4BEF-A763-99765FB1C4EAQ38187867-D4C1652B-5077-4AB3-A09D-21F4EA2838AAQ38481021-4DBFEA71-4404-43EA-91CB-589617BAE3E6Q38780171-490AA169-D83F-4FD9-BB72-A6BA39FD2079Q38808418-F9D92A7E-F441-4856-BEF1-9D528F65820EQ38837451-DF984E06-F7AF-4143-AD4E-D7EEF8EE21A4Q38889475-F834B737-B7EC-4EA4-80DD-1223FCF9D173Q39270529-551BFE0D-8ADD-40A9-92A6-4222E5A5C61BQ39953670-5CD93D3F-E312-4128-A11B-A7DAED4606C9Q40709652-015C2DAB-0049-42AD-A328-90EC4E314D04Q41064004-6FF4455B-2C9E-476B-BDEB-C5ECB83AD273Q41660762-8B863F70-6AEE-4416-8044-63A887E3B241Q41858529-CBA3CCB0-DBBC-415C-8F19-6E7C869D0DEAQ41897701-330DAD7E-E5A3-46E3-B8CD-3631A4072D28Q41914517-56666DD2-9094-4CEB-A728-7C1B9324C5FCQ41980350-D384EAA5-A1C9-4898-AD15-C2D4E529AE05Q47100134-82444D8B-5C69-4E6E-ADAB-1154280FDCBAQ47327932-591EBFC8-A4EC-4881-8B93-2B3389B6F6E3Q48774191-B0203082-4C2E-4B1C-84EA-E1889DCE54B0Q57069735-13C31080-5C8C-4697-99A9-47DB3AC82CE7Q58701352-8F6F6CDA-9582-479F-A3A8-D31AC39E657D
P2860
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Discovery of a small-molecule ...... f2 protein-protein interaction
@ast
Discovery of a small-molecule ...... f2 protein-protein interaction
@en
Discovery of a small-molecule ...... f2 protein-protein interaction
@nl
type
label
Discovery of a small-molecule ...... f2 protein-protein interaction
@ast
Discovery of a small-molecule ...... f2 protein-protein interaction
@en
Discovery of a small-molecule ...... f2 protein-protein interaction
@nl
prefLabel
Discovery of a small-molecule ...... f2 protein-protein interaction
@ast
Discovery of a small-molecule ...... f2 protein-protein interaction
@en
Discovery of a small-molecule ...... f2 protein-protein interaction
@nl
P2093
P2860
P1476
Discovery of a small-molecule ...... f2 protein-protein interaction
@en
P2093
Ah-Ng Tony Kong
Benito Munoz
Carol Khodier
Daigo Inoyama
John E Kerrigan
Lesa J Beamer
Longqin Hu
P2860
P304
P356
10.1016/J.BMCL.2013.03.013
P407
P577
2013-03-14T00:00:00Z