Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.

Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.

Item
http://www.wikidata.org/entity/Q34668049
Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury.Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cellsIdentification of novel small-molecule inducers of fetal hemoglobin using pharmacophore and 'PSEUDO' receptor models.Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobinLiquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.A common signaling pathway is activated in erythroid cells expressing high levels of fetal hemoglobin: a potential role for cAMP-elevating agents in β-globin disorders.Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.Novel approaches to the treatment of sickle cell disease: the potential of histone deacetylase inhibitors.Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia-Current Status and Perspectives in Fetal Hemoglobin Reactivation.Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats.
P2860

Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.

Item
http://www.wikidata.org/entity/Q34668049
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@ast
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@en
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@nl
type
label
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@ast
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@en
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@nl
prefLabel
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@ast
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@en
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P478
P577
P698
P932
P356
P1433
P1476
Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
@en
P2093
P2860
P304
P31
P356
P407
P478
P577
P698
P932