Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. - Wikidata - wikimedia - TriplyDB

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.

http://www.wikidata.org/entity/Q34723868

about

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies.Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.Identification and characterization of mechanistically distinct inducers of gamma-globin transcription Fetal globin induction--can it cure beta thalassemia?Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.Identification of novel small-molecule inducers of fetal hemoglobin using pharmacophore and 'PSEUDO' receptor models.MBD2 contributes to developmental silencing of the human ε-globin gene.Pharmacotherapy in sickle cell disease--state of the art and future prospects Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents.Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.Butyrate histone deacetylase inhibitors.Molecular therapies in beta-thalassaemia.Induction of human fetal hemoglobin expression by adenosine-2',3'-dialdehyde.Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in β-thalassaemia intermedia.A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease Fetal globin gene inducers: novel agents and new potential.A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia.Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia-Current Status and Perspectives in Fetal Hemoglobin Reactivation.A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.Pharmacological induction of neuroglobin expression.Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.Phenylbutyrate induces antimicrobial peptide expression.Bioprotective carnitinoids: lipoic acid, butyrate, and mitochondria-targeting to treat radiation injury: mitochondrial drugs come of age.CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase.A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.Radiation protection and mitigation potential of phenylbutyrate: delivered via oral administration.Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells.Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats.An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.Erythropoiesis: insights into pathophysiology and treatments in 2017.

P2860

Q26742061-1AF30243-C542-4B2D-9D85-C906BE90AF79 Q28551832-8B1C7B69-D16F-4CB6-AAB2-882AA1E48C54 Q30496656-5375F424-1378-45A5-9AA3-21C39FB96037 Q33922774-5F491AC0-2E72-49A8-90D9-FCF78F67A5CF Q34313801-5C225AC4-3E44-405F-AAFD-E35F5E12FE1F Q34469649-92DC061A-74F5-440F-8914-9AF7AEB0D87E Q34668049-E54F188E-CE49-4E6C-AE71-9C505D7EF401 Q34678844-3DBF9B15-AA0B-4921-B7F2-F29EED276A8A Q34706782-69EC5292-8DC9-47F8-8D4F-A6A2E4833307 Q35220342-EC5487B7-E3E5-4C70-9FD2-88EB60C3C7E2 Q35596693-B34C60A1-1E1F-4494-B496-7AF102560571 Q35634572-18209C74-5DE4-4177-98D7-54FB819BC122 Q35690817-CC88C598-6EEF-40E4-A3DF-C79645AE279A Q35849050-21CE842B-CD49-4D8F-AD04-54CF06EB192B Q36478403-DACEB691-A6C6-4A5B-9C8F-04EE5A143635 Q36574546-4F1CC754-BA40-498C-B82A-73AA2C0B9C03 Q36665342-FA16D8AD-3FB5-446C-9CF9-37FCD3BABF33 Q36688921-0B137ED6-41A1-451F-935E-836F7AE3CE9D Q37071189-1D106681-C784-4356-BA6B-C255549C2DD9 Q37524864-74DA40FD-3FB4-48B0-AF21-BE4893328397 Q37524883-545BDE10-38BE-4E01-BAFB-F58394DF616C Q37524888-8BDAC6BF-B2B3-4EA6-A44C-182611A74384 Q37552428-BA0C05AF-A4A2-491E-B440-FC6D67016610 Q37674785-EEE1C3B3-65E9-46EF-B009-A6AC92B152AD Q38743021-B7012DAC-C203-4C34-B263-4C2514DB0161 Q38816924-DC889F40-51A3-4903-9F2C-D41B3D6F2CC3 Q38879274-2C96EFA7-CDF6-4865-A72E-00E2DDFBA4EC Q39390596-89972451-9DB4-4D5A-92CB-B54F89A4FD7C Q39608561-589FC888-FC26-4AA2-B9A9-CEFBF2235A6F Q39639963-1884B8E5-C26F-4686-8CC2-F770C55476A7 Q39796789-7FCD4C30-1543-4FC4-A0AB-C575C5E5A798 Q41953858-31DADDDF-E3D5-4E03-AAED-FCE18A1F55EB Q45073108-44B45494-1E20-4AEE-BCDC-325221178BE5 Q45377608-FA0C9C6E-BDD7-4975-B7BF-C85DA1B6A2DD Q46330013-F743A07A-D711-45DB-8AF3-F11DE450D1C3 Q50484219-0F6DC9BA-353A-48B9-8FF5-0C069F5E4DC3 Q50537208-140AC17E-AC51-41CB-B700-A07494BDC4FC Q52820544-BB332C28-F615-45DC-8DC4-FBD2FB566CDB Q55436035-3F6AC045-8BF1-43E4-B268-5D0D4A76E2A8

P2860

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.

http://www.wikidata.org/entity/Q34723868

description

2002 nî lūn-bûn

@nan

2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@ast

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@en

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@nl

type

label

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@ast

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@en

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@nl

prefLabel

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@ast

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@en

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@nl

P1433

Q34723868-A0EC4943-8E27-4453-96E9-88164AD7F933

P1476

Q34723868-7E3AA23B-6BC3-4707-89DC-9C8E426A6996

P2093

Q34723868-0F4CF61C-4184-4F8F-BD41-5E29389F6BAE

Q34723868-1E11DD01-4DE3-421C-A249-E1A996D40FBC

Q34723868-4641D052-5DCF-4193-B80E-48BAAFA79730

Q34723868-73761DBB-6120-4138-B271-829DCCEBA83F

Q34723868-8938E47B-DD9C-4222-BE19-564232684E3F

P2860

Q34723868-08BFB826-A50E-4093-A1FD-AE3E32CCE7F4

Q34723868-0C133DFC-AE57-456A-AD55-9C3A15132073

Q34723868-27617CDA-772C-4339-BB53-4C12C47A7976

Q34723868-2C9F6609-8B3F-4B73-A724-85D8D82673DA

Q34723868-2EF2DAE5-3BDC-4543-B911-A2E88DECC0D6

Q34723868-3004204A-F1D9-4C3B-B823-4D1AE97574FC

Q34723868-43A55CF4-FDD1-4D47-B905-8D2CE4C83711

Q34723868-4DC18661-BE37-4A6F-AE8D-226D20D09572

Q34723868-5DDE6C14-19E9-4105-889B-E5370F0CFCF5

Q34723868-61CE17E6-1ADA-4440-ADC2-A388A8D738E1

P304

Q34723868-F4056E19-50C5-49DA-BB79-34DD0B78822C

P31

Q34723868-8A0D991A-2664-43C0-8497-0E8695B89AD2

P356

Q34723868-FF8E6D2D-93FE-48CE-9FC5-A8A449765164

P407

Q34723868-3C65D4AE-4562-443C-B54F-F515D0155B79

P433

Q34723868-84276395-A4FD-49B6-86B9-02363942B1C2

P478

Q34723868-EE735ECA-5F3F-410F-9EF3-AE36174D3733

P50

Q34723868-AB5448FB-5931-4B39-BEE5-EA91A36DD90A

P577

Q34723868-E7C3876B-2059-4A2C-A6A5-410B7B37FE8A

P5875

Q34723868-3D5ADDD7-FEA2-4FE6-A75D-C824E32029A6

P698

Q34723868-8796BBC1-D0A1-465C-A65B-9D8C9A8ECF03

P921

Q34723868-F683E363-541D-4A90-A630-D3E0E209CEE5

P932

Q34723868-5FAB0991-F7C6-422D-B05C-EF0623C6F73A

P356

BLOOD-2002-02-0353

P1433

P1476

Short-chain fatty acid derivat ...... on and erythropoiesis in vivo.

@en

P2093

Douglas V Faller

http://www.w3.org/2001/XMLSchema#string

Gary L White

http://www.w3.org/2001/XMLSchema#string

George J Dover

http://www.w3.org/2001/XMLSchema#string

Michael S Boosalis

http://www.w3.org/2001/XMLSchema#string

Susan P Perrine

http://www.w3.org/2001/XMLSchema#string

P2860

Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Induction of fetal hemoglobin in sickle cell disease.

Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching.

Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease.

Pharmacologic modulation of fetal hemoglobin.

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

Therapeutic approaches to hemoglobin switching in treatment of hemoglobinopathies.

Pharmacokinetic study of butyric acid administered in vivo as sodium and arginine butyrate salts.

Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate

P304

4640-4648

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2002-02-0353

http://www.w3.org/2001/XMLSchema#string

P407

P433

13

http://www.w3.org/2001/XMLSchema#string

P478

100

http://www.w3.org/2001/XMLSchema#string

P50

P577

2002-08-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5270688

http://www.w3.org/2001/XMLSchema#string

P698

12393583

http://www.w3.org/2001/XMLSchema#string

P921

P932

4269367

http://www.w3.org/2001/XMLSchema#string