Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation - Wikidata - wikimedia - TriplyDB

Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

http://www.wikidata.org/entity/Q34669076

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Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining Homologous Recombination and Its Role in Carcinogenesis DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients The consequences of Rad51 overexpression for normal and tumor cells RAD51 protein expression is increased in canine mammary carcinomas In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells Characterization of homologous recombination induced by replication inhibition in mammalian cells Sequestration of mammalian Rad51-recombination protein into micronuclei The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein Targeting tumor suppressor networks for cancer therapeutics.Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system.Is homologous recombination really an error-free process?Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54.RAD51 is required for propagation of the germinal nucleus in Tetrahymena thermophila.Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis.Manipulating the mammalian genome by homologous recombination An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines.Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors Meiosis and the evolution of recombination at low mutation rates.Association between the RAD51 135 G>C polymorphism and risk of cancer: a meta-analysis of 19,068 cases and 22,630 controls.BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability.Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines.RecA stimulates sister chromatid exchange and the fidelity of double-strand break repair, but not gene targeting, in plants transformed by Agrobacterium Targeting the homologous recombination pathway by small molecule modulators

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Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

http://www.wikidata.org/entity/Q34669076

description

1998 nî lūn-bûn

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1998 թուականի Յունիսին հրատարակուած գիտական յօդուած

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1998 թվականի հունիսին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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prefLabel

Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Nucleic Acids Research

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Overexpression of Rad51 protei ...... an cells to ionizing radiation

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Cazaux C

http://www.w3.org/2001/XMLSchema#string

Defais M

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Lesca C

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Vispé S

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P2860

Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

Characterization of strand exchange activity of yeast Rad51 protein.

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

Stimulation by Rad52 of yeast Rad51-mediated recombination

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells

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2859-2864

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10.1093/NAR/26.12.2859

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9611228

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147643

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