'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage. - Wikidata - wikimedia - TriplyDB

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

http://www.wikidata.org/entity/Q34686193

about

Mechanisms regulating endothelial permeability Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo.Differential signaling by protease-activated receptors: implications for therapeutic targeting.The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.Role of G protein-coupled receptors in inflammation.Signal transduction by protease-activated receptors Regulation of the protein C anticoagulant and antiinflammatory pathways.Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for antiangiogenic therapy.Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations Cooperative signaling via transcription factors NF-κB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin.Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models.Proteinase-activated receptors in fibroproliferative lung disease.Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis.Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5.Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection.Allosteric modulation of protease-activated receptor signaling.Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity.Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer.Proteases display biased agonism at protease-activated receptors: location matters!Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function.Activated protein C: biased for translation.We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia.Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia.The down regulation of neutrophil oxidative metabolism by S100A8 and S100A9: implication of the protease-activated receptor-2 Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4 A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation.Interface between hemostasis and adaptive immunity Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability.Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.Matrix metalloproteases and PAR1 activation.

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P2860

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

http://www.wikidata.org/entity/Q34686193

description

2007 nî lūn-bûn

@nan

2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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type

label

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

@nl

prefLabel

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

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Nature Immunology

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

@en

P2093

Andrew J Leger

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Anika Agarwal

http://www.w3.org/2001/XMLSchema#string

Athan Kuliopulos

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Claudia Derian

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George Perides

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Lidija Covic

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Nga Nguyen

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Nicole C Kaneider

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P2860

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells

Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis

Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1

Efficacy and safety of recombinant human activated protein C for severe sepsis

The acute respiratory distress syndrome

The pathophysiology and treatment of sepsis

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10.1038/NI1525

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12

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8

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2007-10-28T00:00:00Z

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5879818

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17965715

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3059149

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