Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals.
about
In vitro Models to Evaluate Drug-Induced Hypersensitivity: Potential Test Based on Activation of Dendritic CellsMechanisms of chemical-induced innate immunity in allergic contact dermatitis.Integrated decision strategies for skin sensitization hazardMethyl methacrylate and respiratory sensitization: a critical reviewImplementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathwaySkinSensDB: a curated database for skin sensitization assaysFilling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing.Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Screening of natural compounds as activators of the keap1-nrf2 pathway.A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal testsPredicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing.Development and validation of a new in vitro assay designed to measure contact allergen-triggered oxidative stress in dendritic cells.Acute toxicity testing of chemicals-Opportunities to avoid redundant testing and use alternative approaches.Non-animal sensitization testing: state-of-the-art.Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis.Non-animal test methods for predicting skin sensitization potentials.Photoprotection in changing times - UV filter efficacy and safety, sensitization processes and regulatory aspects.Reporter cell lines for skin sensitization testing.Chemical allergy: translating biology into hazard characterization.Non-animal assessment of skin sensitization hazard: Is an integrated testing strategy needed, and if so what should be integrated?Testing Human Skin and Respiratory Sensitizers-What Is Good Enough?Contact dermatitis: in pursuit of sensitizer's molecular targets through proteomics.Development of novel in vitro photosafety assays focused on the Keap1-Nrf2-ARE pathway.Evaluation of combinations of in vitro sensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization.Evaluation of in silico tools to predict the skin sensitization potential of chemicals.Reactivity of chemical sensitizers toward amino acids in cellulo plays a role in the activation of the Nrf2-ARE pathway in human monocyte dendritic cells and the THP-1 cell line.An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing.Evaluation of the skin sensitization potential of chemicals in THP-1/keratinocyte co-cultures.A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells.Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivityDetoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase.Development of an artificial neural network model for risk assessment of skin sensitization using human cell line activation test, direct peptide reactivity assay, KeratinoSens™ and in silico structure alert parameter.The definition of the applicability domain relevant to skin sensitization for the aromatic nucleophilic substitution mechanism.Nature and kinetics of redox imbalance triggered by respiratory and skin chemical sensitizers on the human monocytic cell line THP-1.Antioxidant response elements: Discovery, classes, regulation and potential applications.
P2860
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P2860
Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals.
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Skin sensitizers induce antiox ...... zation potential of chemicals.
@ast
Skin sensitizers induce antiox ...... zation potential of chemicals.
@en
Skin sensitizers induce antiox ...... zation potential of chemicals.
@nl
type
label
Skin sensitizers induce antiox ...... zation potential of chemicals.
@ast
Skin sensitizers induce antiox ...... zation potential of chemicals.
@en
Skin sensitizers induce antiox ...... zation potential of chemicals.
@nl
prefLabel
Skin sensitizers induce antiox ...... zation potential of chemicals.
@ast
Skin sensitizers induce antiox ...... zation potential of chemicals.
@en
Skin sensitizers induce antiox ...... zation potential of chemicals.
@nl
P2860
P356
P1476
Skin sensitizers induce antiox ...... zation potential of chemicals.
@en
P2093
Andreas Natsch
Roger Emter
P2860
P304
P356
10.1093/TOXSCI/KFM259
P577
2007-10-11T00:00:00Z