In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.
about
Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo EfficacyMedicinal chemistry of adenosine, P2Y and P2X receptors.Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain.Metabolic mapping of A3 adenosine receptor agonist MRS5980Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine.Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.New paradigms in GPCR drug discovery.Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.A binding kinetics study of human adenosine A3 receptor agonists.Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists.Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.Polypharmacology of conformationally locked methanocarba nucleosides.Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
P2860
Q27345188-D3A5AC82-EB9E-4C1E-AC08-E5A446052A7DQ30793386-D9DD9652-F029-439A-BF10-B15BCE10A1B4Q35844532-4C3FBA45-ABEC-4662-81B2-24735E588FDCQ35873582-E9BD6B9B-60A4-49BB-ACCC-F8948C9A03FCQ35896690-3430795E-591F-4426-A2BB-6C5FF13D53FBQ35930748-A053ADFA-1665-41D8-8F40-42F0B9757040Q36088970-4FD75E2F-2131-46B8-A9C7-98DE1FB22504Q36733500-9A99E478-0F7E-41B1-B888-EBFE28700504Q37084901-8ADD6C53-BEE2-4AC4-91D9-5D76C8A1A781Q37140411-B35C8BC7-2467-4C2C-8F19-702CBDECC1B4Q39133269-83D58246-B784-43B4-9066-7355A7A9124FQ39418010-2E4137E4-EE25-4874-B7EE-313FCEDFE4CDQ47804733-BC936695-D1CE-424F-8971-EDA840C13AFAQ48102516-40EDD1F5-9056-4727-840A-AF92F872633CQ48172109-A58F6F4E-4B2E-4A56-9168-3FE622153483Q48226209-38364265-E646-4804-981B-A9B0155B8F5BQ53123581-869C1B7C-F2A1-49E7-8520-88E422C8A12EQ58581253-31C23915-B966-4073-9AD6-ED5A388D1743
P2860
In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@ast
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@en
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@nl
type
label
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@ast
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@en
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@nl
prefLabel
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@ast
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@en
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@nl
P2093
P2860
P50
P921
P356
P1476
In vivo phenotypic screening f ...... 3 adenosine receptor agonists.
@en
P2093
Amanda Finley
Daniela Salvemini
Elizabeth T Gizewski
John A Auchampach
Steven M Moss
P2860
P304
P356
10.1021/JM501021N
P407
P577
2014-11-25T00:00:00Z