Identification of small molecules that modify the protein folding activity of heat shock protein 70.
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Insights into the molecular mechanism of allostery in Hsp70s.Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksIdentification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaKBinding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitroHSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradationHeat shock protein 70 (hsp70) as an emerging drug target.Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK)Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK).Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone ComplementChemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells.The Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisGlutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response.Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2Pharmacological targeting of the Hsp70 chaperone.Potential synergy between tau aggregation inhibitors and tau chaperone modulators.Screening strategies to identify HSP70 modulators to treat Alzheimer's disease.Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.A small molecule inhibitor of inducible heat shock protein 70.Molecular chaperones DnaK and DnaJ share predicted binding sites on most proteins in the E. coli proteome.Chemically accessible hsp90 inhibitor that does not induce a heat shock responseA heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock responseSpecific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.Development of fluorescence polarization assays for the molecular chaperone Hsp70 family members: Hsp72 and DnaK.From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex.
P2860
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P2860
Identification of small molecules that modify the protein folding activity of heat shock protein 70.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Identification of small molecu ...... vity of heat shock protein 70.
@ast
Identification of small molecu ...... vity of heat shock protein 70.
@en
Identification of small molecu ...... vity of heat shock protein 70.
@nl
type
label
Identification of small molecu ...... vity of heat shock protein 70.
@ast
Identification of small molecu ...... vity of heat shock protein 70.
@en
Identification of small molecu ...... vity of heat shock protein 70.
@nl
prefLabel
Identification of small molecu ...... vity of heat shock protein 70.
@ast
Identification of small molecu ...... vity of heat shock protein 70.
@en
Identification of small molecu ...... vity of heat shock protein 70.
@nl
P356
P1476
Identification of small molecu ...... vity of heat shock protein 70.
@en
P2093
Jason E Gestwicki
Susanne Wisén
P304
P356
10.1016/J.AB.2007.12.009
P407
P577
2007-12-14T00:00:00Z