A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed
about
Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cyclePCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexesThe INT6 cancer gene and MEK signaling pathways converge during zebrafish developmentThe human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasomeInt6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeastInt6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregationCell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts.Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development.Hypoxia-inducible factor as an angiogenic master switchINT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis.The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.Activation of AP-1-dependent transcription by a truncated translation initiation factor.Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.Evidence for the transforming activity of a truncated Int6 gene, in vitro.Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.Plant initiation factor 3 subunit composition resembles mammalian initiation factor 3 and has a novel subunit.Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h.Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits.An oncogenic role of eIF3e/INT6 in human breast cancer.Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation.Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression
P2860
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P2860
A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
A fission yeast homolog of Int ...... resistance when overexpressed
@ast
A fission yeast homolog of Int ...... resistance when overexpressed
@en
A fission yeast homolog of Int ...... resistance when overexpressed
@nl
type
label
A fission yeast homolog of Int ...... resistance when overexpressed
@ast
A fission yeast homolog of Int ...... resistance when overexpressed
@en
A fission yeast homolog of Int ...... resistance when overexpressed
@nl
prefLabel
A fission yeast homolog of Int ...... resistance when overexpressed
@ast
A fission yeast homolog of Int ...... resistance when overexpressed
@en
A fission yeast homolog of Int ...... resistance when overexpressed
@nl
P2093
P2860
P356
P1476
A fission yeast homolog of Int ...... resistance when overexpressed
@en
P2093
P2860
P304
P356
10.1091/MBC.11.11.3993
P577
2000-11-01T00:00:00Z