Distinct requirements for Ras oncogenesis in human versus mouse cells. - Wikidata - wikimedia - TriplyDB

Distinct requirements for Ras oncogenesis in human versus mouse cells.

Distinct requirements for Ras oncogenesis in human versus mouse cells.

http://www.wikidata.org/entity/Q34787097

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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways The tumor suppressor PP2A Abeta regulates the RalA GTPase Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6 RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype Genetic alterations in pancreatic carcinoma Engineered Swine Models of Cancer The Exocyst at a Glance The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis Copper is required for oncogenic BRAF signalling and tumorigenesis Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization Ral GTPases: crucial mediators of exocytosis and tumourigenesis Ral GTPases in tumorigenesis: emerging from the shadows Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9 Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors BRAF mutation predicts sensitivity to MEK inhibition Ras oncogenes: split personalities Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.Ras history: The saga continues.Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster.R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes.Ras effector switching promotes divergent cell fates in C. elegans vulval patterning.RALA and RALBP1 regulate mitochondrial fission at mitosis RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells.Targeting pathways downstream of KRAS in lung adenocarcinoma.RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1 Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.Distinct functions of POT1 at telomeres.TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.

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P2860

Distinct requirements for Ras oncogenesis in human versus mouse cells.

http://www.wikidata.org/entity/Q34787097

description

2002 nî lūn-bûn

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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի օգոստոսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@ast

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@en

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@nl

type

label

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@ast

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@en

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@nl

prefLabel

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@ast

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@en

Distinct requirements for Ras oncogenesis in human versus mouse cells.

@nl

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Genes & Development

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Distinct requirements for Ras oncogenesis in human versus mouse cells.

@en

P2093

Antoine E Karnoub

http://www.w3.org/2001/XMLSchema#string

Channing J Der

http://www.w3.org/2001/XMLSchema#string

Christopher M Counter

http://www.w3.org/2001/XMLSchema#string

Jeremy N Rich

http://www.w3.org/2001/XMLSchema#string

Joel H Elconin

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Nesrin M Hamad

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Robert T Abraham

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Wenli Bai

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P2860

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral

Protein binding and signaling properties of RIN1 suggest a unique effector function

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Extension of life-span by introduction of telomerase into normal human cells

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf

PIK3CA as an oncogene in cervical cancer

A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras

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2045-2057

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scholarly article

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10.1101/GAD.993902

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16

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16

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2002-08-01T00:00:00Z

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11204765

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12183360

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186434

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