KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia - Wikidata - wikimedia - TriplyDB

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

http://www.wikidata.org/entity/Q34870589

about

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity Epigenomics of leukemia: from mechanisms to therapeutic applications Mechanisms of epigenetic regulation of leukemia onset and progression Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Chromatin dynamics during cellular reprogramming Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1 Associations between Blood and Urine Arsenic Concentrations and Global Levels of Post-Translational Histone Modifications in Bangladeshi Men and Women Co-regulation of histone-modifying enzymes in cancer Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.Mutations of Chromatin Structure Regulating Genes in Human Malignancies.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes.Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.Chromatin proteins and modifications as drug targets.Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.Chromatin and oxygen sensing in the context of JmjC histone demethylases A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.Reactive oxygen species in eradicating acute myeloid leukemic stem cells Epigenetic changes: a common theme in acute myelogenous leukemogenesis Epigenetic reprogramming in cancer.Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes.RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases Roles of histone methyl-modifying enzymes in development and progression of cancer.Histone lysine demethylases as targets for anticancer therapy.The roles of Jumonji-type oxygenases in human disease.Chromatin modifiers and the promise of epigenetic therapy in acute leukemia Targeting the histone orthography of cancer: drugs for writers, erasers and readers.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Post-translational control of transcription factors: methylation ranks highly.

P2860

Q24301878-D111AEB6-C058-4600-8175-6B0556198334 Q26823403-CBC18BD6-A687-4325-AE0B-F3F320C162F8 Q26861785-35A3FCA7-C2F0-4A0C-BDA3-E8569D163E7E Q26994739-573E5C8A-10A4-4055-9356-FB9FAA7A3A65 Q27003401-57324FE4-BDE8-4B2A-BE34-AD1F16F7993A Q27676706-97FB9DC1-A63E-4E2F-BC40-AB7066C296E5 Q27681315-D0CB1A81-FD85-4C7F-AD94-45289ED550AB Q27727752-5AE8B9E3-FF81-459E-955D-CBC1197F5B84 Q28386100-AEFA5107-4EB6-4466-B26E-9033298CA79F Q28476656-E13A1040-F624-4DEC-BCEB-FF77811C95CB Q33292152-5C02D441-F6EA-4000-8CD6-AAF1D8A99D50 Q33600399-8F49F7A4-EE4A-4D8C-AC44-F36869E258BB Q33666543-9CA5AC26-3C9A-4A6E-8966-93C62AC5C9C2 Q33834910-4B202A35-DA71-4292-90B2-5470F558E723 Q34027680-BF7497D9-C4F5-48BD-9538-6B00E18377AB Q34038652-6FC8F56F-FE84-49A8-BC9F-531D9D65D63A Q34071417-268EE2FD-293F-4A40-A8DB-C35FAD8E6B01 Q34103385-B2F699CE-2B27-4244-A917-F4A2BEAF69E5 Q34254480-789D1815-E896-4342-A8C2-A56CED97F5D4 Q34259150-E64E9B03-1036-44E6-BB88-1A39AB76A1EF Q34322749-6AEE53A2-986F-4847-BA70-304FDD1D426A Q35254822-8B9C2BC0-9586-444C-A675-547475855098 Q35661995-F2BB4BE3-C863-41F1-B457-A678FD809702 Q36155124-5E558CAB-C18A-42F2-9C0B-810FE792A3A8 Q36618609-35BC2A7C-721E-41A1-8AD1-89A6398D4B4E Q36936680-6F921146-9C0F-4EE1-B1B7-007750F93340 Q36956949-C9ECE35D-22AE-48D8-8FDC-F60589924F31 Q37043785-8C377CDA-7ED3-42EF-893C-92A67CBA0F56 Q37116613-8F805A6A-AAB2-49DA-84BB-15A1C7D1D576 Q37291110-534DD8CB-C1C7-4D06-B4D0-F491BEB195D5 Q37339132-71627715-82FF-4226-914D-2590B3DDCADF Q37621929-D6B50725-9BF3-479F-8513-8E9E9052B419 Q37957006-F38F37F7-4335-463B-9283-265C14090144 Q38096423-DEE3EB21-AE11-4089-B317-091A62773DD6 Q38162717-3EC65713-3B3D-4AB1-9618-2D2CAEA67D1B Q38192028-613073E0-48FF-44A6-A15E-DAB013CAF745 Q38194444-89319A0B-D2BA-40AA-81F6-41DB7CE047DC Q38231327-395581FA-3D8F-4B73-8C49-81FFB2517F21 Q38233723-783DA48E-2C48-4971-A03F-3C9B453DCFF1 Q38592178-BB81EB63-47E6-4AAB-8499-8C77DA906A24

P2860

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

http://www.wikidata.org/entity/Q34870589

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@ast

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@en

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@nl

type

label

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@ast

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@en

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@nl

prefLabel

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@ast

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@en

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@nl

P1433

Q34870589-2F0733F2-EE73-4617-9E1A-66CC51C7FEA7

P1476

Q34870589-350ACAB1-6898-4306-81BA-7F2113CE942F

P2093

Q34870589-12FDE57C-AEA9-440C-A19A-B5B1BAAC4422

Q34870589-52F14AD1-C595-4CEA-B14D-669F7CB1C617

P2860

Q34870589-0D0A138F-978E-4DD2-ABA6-454717DD4D80

Q34870589-12C0D9DA-8F84-42A6-BD0E-17CD8A80E5FC

Q34870589-13CFF65F-D8E1-450F-A4A7-E53BEDB362C4

Q34870589-1865FD53-F6DE-4F2F-918F-0DD2347F1F08

Q34870589-220FFF5A-38F9-4C64-86EA-9FE41914DF23

Q34870589-3761EB34-4C71-42E3-AA3F-2665D10BB142

Q34870589-3BE71202-F3FC-43B7-BAB3-369F3E75AD9E

Q34870589-3C60EABD-CA29-44DC-9F3C-64C3724E08A8

Q34870589-3E1E8163-7FB3-45C1-9178-074C6D74E9B6

Q34870589-44244BC9-F419-4C88-8D1E-9BB28C394285

P304

Q34870589-EE941EE9-9E33-48F1-A79C-67314FAA5C00

P31

Q34870589-745F5775-1601-45EC-9ED1-F56E6C35F32E

P356

Q34870589-FFAF6E69-1EFA-4727-9A9C-A37C7770DFFA

P407

Q34870589-7FE616BF-943F-4D88-8455-7F6CEF302E54

P433

Q34870589-01B48C79-8490-4F00-8B57-49C2E7CBAA8B

P478

Q34870589-DC68AE69-7D7B-4C78-89E7-6B6524EA5B51

P50

Q34870589-12043D45-F7AE-4FAB-BC58-DD61131A7100

P577

Q34870589-194C7477-048D-4499-BADC-2B41887DAB2E

P5875

Q34870589-99E0FE0F-1AE7-4B27-A16C-EFF5329B29BD

P698

Q34870589-247DF663-E815-4FCC-A3C2-EC9ED15D7888

P921

Q34870589-073A018E-A2D1-4924-9C15-8DD7DB20CE55

P932

Q34870589-C5A81B9C-C807-4C58-855C-13F7BBA9D9B5

P356

BLOOD-2010-10-312736

P1433

P1476

KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia

@en

P2093

Anh Tram Nguyen

http://www.w3.org/2001/XMLSchema#string

Jin He

http://www.w3.org/2001/XMLSchema#string

P2860

Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets

Role of histone H2A ubiquitination in Polycomb silencing

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

Role of hPHF1 in H3K27 methylation and Hox gene silencing

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Histone demethylation by a family of JmjC domain-containing proteins.

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

P304

3869-3880

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2010-10-312736

http://www.w3.org/2001/XMLSchema#string

P407

P433

14

http://www.w3.org/2001/XMLSchema#string

P478

117

http://www.w3.org/2001/XMLSchema#string

P50

P577

2011-02-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49826484

http://www.w3.org/2001/XMLSchema#string

P698

21310926

http://www.w3.org/2001/XMLSchema#string

P921

P932

3083299

http://www.w3.org/2001/XMLSchema#string