Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures
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Posttranslational Modifications and the Immunogenicity of BiotherapeuticsStructure-based prediction of asparagine and aspartate degradation sites in antibody variable regionsIn vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activityOxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodiesConsiderations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein.Prediction of Spontaneous Protein Deamidation from Sequence-Derived Secondary Structure and Intrinsic Disorder.Functional assessment of antibody oxidation by native mass spectrometry.Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes.Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer.Assessment of disulfide and hinge modifications in monoclonal antibodiesEffects of carboxypeptidase B treatment and elevated temperature on recombinant monoclonal antibody charge variants in cation-exchange chromatography analysis.Molecular polygamy: The promiscuity of l-phenylalanyl-tRNA-synthetase triggers misincorporation of meta- and ortho-tyrosine in monoclonal antibodies expressed by Chinese hamster ovary cells.Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry.Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometryEngineering deamidation-susceptible asparagines leads to improved stability to thermal cycling in a lipase.8(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland.Strategies for analysis of isomeric peptides.Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles.Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditionsProtein deamidation in biopharmaceutical manufacture: understanding, control and impactDetailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry
P2860
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P2860
Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures
description
2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
Simultaneous assessment of Asp ...... ation at elevated temperatures
@ast
Simultaneous assessment of Asp ...... ation at elevated temperatures
@en
Simultaneous assessment of Asp ...... ation at elevated temperatures
@nl
type
label
Simultaneous assessment of Asp ...... ation at elevated temperatures
@ast
Simultaneous assessment of Asp ...... ation at elevated temperatures
@en
Simultaneous assessment of Asp ...... ation at elevated temperatures
@nl
prefLabel
Simultaneous assessment of Asp ...... ation at elevated temperatures
@ast
Simultaneous assessment of Asp ...... ation at elevated temperatures
@en
Simultaneous assessment of Asp ...... ation at elevated temperatures
@nl
P2093
P2860
P3181
P1433
P1476
Simultaneous assessment of Asp ...... ation at elevated temperatures
@en
P2093
Andreas Petzold
Bernd Moritz
Boris Zimmermann
Dietmar Reusch
Jan Olaf Stracke
Katharina Diepold
Katrin Bomans
Michael Mølhøj
Michael Wiedmann
Robert Mueller
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0030295
P407
P577
2012-01-01T00:00:00Z