Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.
about
Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.The proton-coupled folate transporter: physiological and pharmacological roles.Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorptionMechanisms of membrane transport of folates into cells and across epithelia.Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphateThe human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.The intestinal absorption of folates.Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorptionRandom mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of functionIdentification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1)A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitorEnhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expressionThe major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Thymidylate synthase inhibitors for non-small cell lung cancer.Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.Cancer chemotherapy: targeting folic acid synthesis.Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.Concentrative transport of antifolates mediated by the proton-coupled folate transporter (PCFT, SLC46A1); augmentation by a HEPES buffer.
P2860
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P2860
Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Hypermethylation of the human ...... late-resistant HeLa cell line.
@ast
Hypermethylation of the human ...... late-resistant HeLa cell line.
@en
Hypermethylation of the human proton-coupled folate transporter
@nl
type
label
Hypermethylation of the human ...... late-resistant HeLa cell line.
@ast
Hypermethylation of the human ...... late-resistant HeLa cell line.
@en
Hypermethylation of the human proton-coupled folate transporter
@nl
prefLabel
Hypermethylation of the human ...... late-resistant HeLa cell line.
@ast
Hypermethylation of the human ...... late-resistant HeLa cell line.
@en
Hypermethylation of the human proton-coupled folate transporter
@nl
P2093
P2860
P1476
Hypermethylation of the human ...... late-resistant HeLa cell line.
@en
P2093
I David Goldman
Joseph Locker
Ndeye Khady Diop-Bove
Rongbao Zhao
P2860
P304
P356
10.1158/1535-7163.MCT-08-0938
P577
2009-08-11T00:00:00Z