Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
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Withaferin-A--A Natural Anticancer Agent with Pleitropic Mechanisms of ActionA Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway EngineeringWithaferin a alters intermediate filament organization, cell shape and behaviorGolden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathwaysWithaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cellsCombinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiationIn vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index.Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma.Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells.FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation.Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin ADevelopment of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species.Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast cancer cellsProstate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologicallyWithaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells.Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells.Withaferin A synergizes the therapeutic effect of doxorubicin through ROS-mediated autophagy in ovarian cancerWithanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance.Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple MyelomaRegulation of the mammalian heat shock factor 1.Withaferin a suppresses estrogen receptor-α expression in human breast cancer cellsOxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.Effect of Withania somnifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV/Neu mice.Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells.Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin AWithania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells.Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines.Anti-cancer activity of withaferin A in B-cell lymphoma.The Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Physalis peruviana) with Potential Anti-inflammatory and Cancer Prevention ActivitiesWithania somnifera Root Extract Enhances Chemotherapy through 'Priming'.Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach.Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas.Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells.
P2860
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P2860
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
@ast
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
@en
type
label
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
@ast
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
@en
prefLabel
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
@ast
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
@en
P2093
P2860
P1476
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
@en
P2093
A A Leslie Gunatilaka
Adel Hamza
Bryan Newman
Chang-Guo Zhan
Mancang Gu
P2860
P304
P356
10.1016/J.BCP.2009.09.017
P407
P577
2010-02-01T00:00:00Z