Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains
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The Role of Amyloid-β Oligomers in Toxicity, Propagation, and ImmunotherapyNeurodegenerative diseases: expanding the prion conceptDepletion of microglia and inhibition of exosome synthesis halt tau propagation.Post-translational modifications in PrP expand the conformational diversity of prions in vivoPropagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Roles of tau protein in health and disease.Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue.PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connectionsTransport of cargo from periphery to brain by circulating monocytes.Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.Prion-like propagation as a pathogenic principle in frontotemporal dementia.Potential mechanisms and implications for the formation of tau oligomeric strains.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Exosomes in the Pathology of Neurodegenerative Diseases.The Prion-Like Behavior of Assembled Tau in Transgenic Mice.Neurodegenerative Disease Transmission and Transgenesis in Mice.Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of diseaseAbsence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's DiseaseEmerging Diagnostic and Therapeutic Strategies for Tauopathies.A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau.Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.Practical considerations for choosing a mouse model of Alzheimer's disease.Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies.Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease.Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice.Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain.GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.The use of mouse models to study cell-to-cell transmission of pathological tau.Widespread tau seeding activity at early Braak stages.Diversity of astroglial responses across human neurodegenerative disorders and brain aging.Protein astrogliopathies in human neurodegenerative diseases and aging.Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.Analysis of Amyloid-β Pathology Spread in Mouse Models Suggests Spread Is Driven by Spatial Proximity, Not Connectivity.
P2860
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P2860
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains
description
2014 nî lūn-bûn
@nan
2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Differential induction and spr ...... rticobasal degeneration brains
@ast
Differential induction and spr ...... rticobasal degeneration brains
@en
type
label
Differential induction and spr ...... rticobasal degeneration brains
@ast
Differential induction and spr ...... rticobasal degeneration brains
@en
prefLabel
Differential induction and spr ...... rticobasal degeneration brains
@ast
Differential induction and spr ...... rticobasal degeneration brains
@en
P2093
P2860
P1476
Differential induction and spr ...... rticobasal degeneration brains
@en
P2093
Kevin M Raible
Michiyo Iba
Susana Boluda
Virginia M-Y Lee
P2860
P2888
P304
P356
10.1007/S00401-014-1373-0
P577
2014-12-24T00:00:00Z