No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
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A global reference for human genetic variationHuman Knockout Carriers: Dead, Diseased, Healthy, or Improved?The Simons Genome Diversity Project: 300 genomes from 142 diverse populationsUnderstanding rare and common diseases in the context of human evolutionEvolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinentVariation in the molecular clock of primatesGenetics of Type 2 Diabetes: the Power of Isolated Populations.Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data.Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.Rapid evolution of the human mutation spectrumHealth and population effects of rare gene knockouts in adult humans with related parentsBottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.The Accumulation of Deleterious Mutations as a Consequence of Domestication and Improvement in Sunflowers and Other Compositae Crops.Genetic variants in DNA double-strand break repair genes and risk of salivary gland carcinoma: a case-control studyThe role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases.Dominance of Deleterious Alleles Controls the Response to a Population BottleneckOrigin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations.Secondary findings and carrier test frequencies in a large multiethnic sample.The Genetic Cost of Neanderthal Introgression.Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypesGlobal diversity, population stratification, and selection of human copy-number variation.Secondary structure impacts patterns of selection in human lncRNAs.Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys.The Strength of Selection against Neanderthal Introgression.Estimating the selective effects of heterozygous protein-truncating variants from human exome data.Patterns of deleterious variation between human populations reveal an unbalanced load.Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.Estimating the mutation load in human genomesCharacterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery.Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry.A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome.Whole-genome sequencing of six Mauritian Cynomolgus macaques (Macaca fascicularis) reveals a genome-wide pattern of polymorphisms under extreme population bottleneck.A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations.Living in an adaptive world: Genomic dissection of the genus Homo and its immune response.Genetic Diversity and the Efficacy of Purifying Selection across Plant and Animal Species.The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.Recent demography drives changes in linked selection across the maize genome.When Is Selection Effective?
P2860
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P2860
No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
No evidence that selection has ...... in Europeans than in Africans
@ast
No evidence that selection has ...... in Europeans than in Africans
@en
type
label
No evidence that selection has ...... in Europeans than in Africans
@ast
No evidence that selection has ...... in Europeans than in Africans
@en
prefLabel
No evidence that selection has ...... in Europeans than in Africans
@ast
No evidence that selection has ...... in Europeans than in Africans
@en
P2093
P2860
P356
P1433
P1476
No evidence that selection has ...... in Europeans than in Africans
@en
P2093
Daniel Balick
David Reich
Ivan Adzhubei
Shamil Sunyaev
P2860
P2888
P304
P356
10.1038/NG.3186
P407
P50
P577
2015-01-12T00:00:00Z