A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.
about
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome.Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odysseyThe bacterial ribosome as a target for antibioticsDeleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics.Comparison of the sensitivities of WaterLOGSY and saturation transfer difference NMR experiments.Selection of small peptides, inhibitors of translation.Combined antimicrobial resistance in Enterococcus faecium isolated from chickens.Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNAThe function and synthesis of ribosomes.Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA bindingDifferential effects of thiopeptide and orthosomycin antibiotics on translational GTPases.Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain.Vancomycin resistance: occurrence, mechanisms and strategies to combat it.Discovery of a small molecule that inhibits bacterial ribosome biogenesis.A comprehensive review of glycosylated bacterial natural products.Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamilyRibosomal proteins in the spotlight.The ribosomal peptidyl transferase center: structure, function, evolution, inhibition.Antibiotics and the ribosome.Bactobolin resistance is conferred by mutations in the L2 ribosomal protein.Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding.Tools for characterizing bacterial protein synthesis inhibitors.Strategies for the design of RNA-binding small molecules.How to cope with the quest for new antibiotics.Bioactive oligosaccharide natural products.The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme.Interaction of avilamycin with ribosomes and resistance caused by mutations in 23S rRNA.Bacterial Protein Synthesis as a Target for Antibiotic Inhibition.Mutations in ribosomal protein L16 and in 23S rRNA in Enterococcus strains for which evernimicin MICs differStructural signatures of antibiotic binding sites on the ribosome.Unusually Stable Picoloyl-Protected Trimethylsilyl Glycosides for Nonsymmetrical 1,1'-Glycosylation and Synthesis of 1,1'-Disaccharides with Diverse Configurations.EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance.The structure of helix 89 of 23S rRNA is important for peptidyl transferase function of Escherichia coli ribosome.Potential new antibiotic sites in the ribosome revealed by deleterious mutations in RNA of the large ribosomal subunit.
P2860
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P2860
A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
A novel site of antibiotic act ...... h the large ribosomal subunit.
@ast
A novel site of antibiotic act ...... h the large ribosomal subunit.
@en
type
label
A novel site of antibiotic act ...... h the large ribosomal subunit.
@ast
A novel site of antibiotic act ...... h the large ribosomal subunit.
@en
prefLabel
A novel site of antibiotic act ...... h the large ribosomal subunit.
@ast
A novel site of antibiotic act ...... h the large ribosomal subunit.
@en
P2093
P2860
P356
P1476
A novel site of antibiotic act ...... th the large ribosomal subunit
@en
P2093
A S Mankin
P M McNicholas
P2860
P304
P356
10.1073/PNAS.071527498
P407
P50
P577
2001-03-20T00:00:00Z