Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
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Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complexPKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complexMolecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoformDeletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesisSelective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiationAKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complexPhosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analoguesCardiac cAMP: production, hydrolysis, modulation and detectionPDE4 as a target for cognition enhancementThe role of ventral striatal cAMP signaling in stress-induced behaviors.The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulationsHuman PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary changeThe cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cellsRACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5DISC1: Structure, Function, and Therapeutic Potential for Major Mental IllnessSubcellular location of PKA controls striatal plasticity: stochastic simulations in spiny dendritesTemporal sensitivity of protein kinase a activation in late-phase long term potentiationInotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heartAttenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2TSH signalling and cancer.Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia.Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiationCytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuitABCD of the phosphodiesterase family: interaction and differential activity in COPDPDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationThe upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsControl of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract.Compartmentalization of beta-adrenergic signals in cardiomyocytes.
P2860
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P2860
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Long PDE4 cAMP specific phosph ...... ream Conserved Region 1 (UCR1)
@en
type
label
Long PDE4 cAMP specific phosph ...... ream Conserved Region 1 (UCR1)
@en
prefLabel
Long PDE4 cAMP specific phosph ...... ream Conserved Region 1 (UCR1)
@en
P2093
P2860
P356
P1476
Long PDE4 cAMP specific phosph ...... ream Conserved Region 1 (UCR1)
@en
P2093
Carolynn MacKenzie
George S Baillie
Gino van Heeke
Ian McPhee
Jenni Millen
Matthew B Beard
Rachael Seamons
Simon J MacKenzie
Theresa McSorley
P2860
P304
P356
10.1038/SJ.BJP.0704743
P407
P577
2002-06-01T00:00:00Z