Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis.
about
PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activityNicotine receptors and depression: revisiting and revising the cholinergic hypothesisα7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimumCHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injuryCreating an 7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein: CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSESNicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory ActivityThe prototoxin LYPD6B modulates heteromeric α3β4-containing nicotinic acetylcholine receptors, but not α7 homomers.nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives.Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptorsTC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia.Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats.Cholinergic axons modulate GABAergic signaling among hippocampal interneurons via postsynaptic alpha 7 nicotinic receptorsWater-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperaturesHigh throughput electrophysiology with Xenopus oocytesPhysiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia.Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.Virtual screening against acetylcholine binding proteinα7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces.The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.{alpha}7-nAChR-mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental colitisCysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeperLack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptorsMerging old and new perspectives on nicotinic acetylcholine receptorsThe effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.The effective opening of nicotinic acetylcholine receptors with single agonist binding sitesModeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonistsA type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats.Nicotinic and muscarinic acetylcholine receptors shape ganglion cell response properties.The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.Gestational nicotine exposure regulates expression of AMPA and NMDA receptors and their signaling apparatus in developing and adult rat hippocampus.High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-conceptα6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.
P2860
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P2860
Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Comparative pharmacology of ra ...... cted with net charge analysis.
@en
type
label
Comparative pharmacology of ra ...... cted with net charge analysis.
@en
prefLabel
Comparative pharmacology of ra ...... cted with net charge analysis.
@en
P2860
P356
P1476
Comparative pharmacology of ra ...... cted with net charge analysis.
@en
P2093
Julia K Porter Papke
Roger L Papke
P2860
P356
10.1038/SJ.BJP.0704833
P407
P577
2002-09-01T00:00:00Z