G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. - Wikidata - wikimedia - TriplyDB

G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.

G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.

http://www.wikidata.org/entity/Q35046020

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Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6 G-protein-coupled receptor kinases in inflammation and disease Multiple actions of spinophilin regulate mu opioid receptor function GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization.The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.How to design an opioid drug that causes reduced tolerance and dependence.Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.Agonist-selective mechanisms of GPCR desensitization Opioid receptor desensitization: mechanisms and its link to tolerance Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.G protein-coupled receptor kinases: more than just kinases and not only for GPCRs Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples.Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms.Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning.Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neurons Ligand-directed signalling within the opioid receptor family.The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Tolerance to the antinociceptive and hypothermic effects of morphine is mediated by multiple isoforms of c-Jun N-terminal kinase.Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins Opioid receptor trafficking and signaling: what happens after opioid receptor activation?Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors.Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons.Modified 'Joyce model' of opioid dependence/withdrawal.Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice.Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat.The dark side of opioids in pain management: basic science explains clinical observation.Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.

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P2860

G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.

http://www.wikidata.org/entity/Q35046020

description

2003 nî lūn-bûn

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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

G-protein receptor kinase 3 (G ...... nce but not opioid withdrawal.

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G-protein receptor kinase 3 (G ...... nce but not opioid withdrawal.

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G-protein receptor kinase 3 (G ...... nce but not opioid withdrawal.

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G-protein receptor kinase 3 (G ...... nce but not opioid withdrawal.

@en

P2093

Charles Chavkin

http://www.w3.org/2001/XMLSchema#string

Gregory W Terman

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Janet Lowe

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Marc G Caron

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Robert J Lefkowitz

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Wenzhen Jin

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Young-Pyo Cheong

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P2860

Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

Mu opioid analgesia and analgesic tolerance in two mouse strains: C57BL/6 and 129/SvJ.

Pavlovian psychopharmacology: the associative basis of tolerance.

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.

Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.

Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin.

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55-64

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10.1038/SJ.BJP.0705595

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