Evolutionary medicine: from dwarf model systems to healthy centenarians?
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A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in miceDelayed and accelerated aging share common longevity assurance mechanismsLife span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9Cancer is a preventable disease that requires major lifestyle changesTwo endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levelsExtension of chronological life span in yeast by decreased TOR pathway signalingGrowth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humansRole of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models.Autophagy: a new target for nonalcoholic fatty liver disease therapyDietary restriction with and without caloric restriction for healthy agingHealthy aging: is smaller better? - a mini-reviewAdaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in miceThe Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span.Links between growth hormone and aging.The vacuolar transporter chaperone (VTC) complex is required for microautophagyGenome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.Haploinsufficiency of akt1 prolongs the lifespan of miceIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesins-7 Gene expression is partially regulated by the DAF-16/IIS signaling pathway in Caenorhabditis elegans under celecoxib interventionMaternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspringAutophagy in health and disease: a double-edged swordEgr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.DNA replication stress is a determinant of chronological lifespan in budding yeast.An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generationNo intra-locus sexual conflict over reproductive fitness or ageing in field crickets.Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.C. elegans feeding defective mutants have shorter body lengths and increased autophagyImpaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.Significant and systematic expression differentiation in long-lived yeast strainsGenomic instability is associated with natural life span variation in Saccharomyces cerevisiae.Regulation of metabolism in Caenorhabditis elegans longevityPhysiological frailty index (PFI): quantitative in-life estimate of individual biological age in miceComparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant.Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cellsFasting and cancer treatment in humans: A case series report.The contribution of visceral fat to improved insulin signaling in Ames dwarf mice.Calorie restriction and cancer prevention: metabolic and molecular mechanisms.Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
P2860
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P2860
Evolutionary medicine: from dwarf model systems to healthy centenarians?
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Evolutionary medicine: from dwarf model systems to healthy centenarians?
@ast
Evolutionary medicine: from dwarf model systems to healthy centenarians?
@en
type
label
Evolutionary medicine: from dwarf model systems to healthy centenarians?
@ast
Evolutionary medicine: from dwarf model systems to healthy centenarians?
@en
prefLabel
Evolutionary medicine: from dwarf model systems to healthy centenarians?
@ast
Evolutionary medicine: from dwarf model systems to healthy centenarians?
@en
P356
P1433
P1476
Evolutionary medicine: from dwarf model systems to healthy centenarians?
@en
P2093
Caleb E Finch
Valter D Longo
P304
P356
10.1126/SCIENCE.1077991
P407
P577
2003-02-01T00:00:00Z