Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice.
about
Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradationChondromodulin-I maintains cardiac valvular function by preventing angiogenesisPref-1 regulates mesenchymal cell commitment and differentiation through Sox9Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cellsThe Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal developmentWhere tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical loadThe life cycle of chondrocytes in the developing skeleton.On the evolutionary relationship between chondrocytes and osteoblastsTranscriptional regulatory cascades in Runx2-dependent bone developmentA pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturationLoss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone developmentBasic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stagesCritical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossificationNkx3.2-mediated repression of Runx2 promotes chondrogenic differentiationTemporal and spatial expression of a novel zinc finger transcription factor, AJ18, in developing murine skeletal tissuesFibroblast growth factor signaling regulates Dach1 expression during skeletal developmentPhenotypic changes in dentition of Runx2 homozygote-null mutant miceInvolvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formationDistribution of the transcription factors Sox9, AP-2, and [delta]EF1 in adult murine articular and meniscal cartilage and growth plateRunx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehogThe high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiationGrowth defect in Grg5 null mice is associated with reduced Ihh signaling in growth platesDlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossificationReduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytesLymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoterTranscriptional coactivation of bone-specific transcription factor Cbfa1 by TAZSnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner.Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotypeIdentification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57.Role of the progressive ankylosis gene (ank) in cartilage mineralization.Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisition regulated by microRNAs.Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors.GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytesThe gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues.Genetic disorders of the skeleton: a developmental approachSox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plateDysregulation of chondrogenesis in human cleidocranial dysplasiaHaploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems.
P2860
Q24296392-4E2BCBE1-B074-48ED-8E47-A5DD0AA9B697Q24303617-09E26014-8DB9-4120-9CEB-141CAA07D17CQ24654674-EA13DA82-9079-4100-819B-67AF8A121A97Q24655929-D1A5C293-8D63-4031-ACD2-3D7C0E54F0D3Q24675473-FE8C1285-92F6-4BBC-A65F-674915A8D31AQ24684257-1493BF18-7EAD-465F-B9F3-8040C69F0281Q24806072-684D806A-4EB9-4A65-ADBA-499CEE0417C6Q26781138-A7D534C2-4CFF-4507-AB84-FB53CF70BCBFQ26830666-F8AFAE45-F6BE-40C3-883F-CFCF049FCEC2Q26995910-8EB0D84C-2B7F-4B2B-83CA-DDC71AE370EAQ27345064-D4286CBA-0CD3-4941-93F3-71C3EBD0C91CQ28207957-C43476FB-1701-4182-9027-A6F125C71013Q28505336-79BCBDFC-8183-44B4-A5C0-16C2A1502E90Q28506917-8F8C4182-AC7A-4A0A-903E-70FF78136AB3Q28507280-2BA19E78-F213-4334-86C9-EE6EFF35E8C7Q28507465-477A543D-5858-4AD7-AC33-5617E80E0438Q28508216-69AA5604-57CA-4232-877D-943FEDE2BAF0Q28511390-1F9E0D02-FD15-46AF-B266-F2FB2817F0ACQ28511841-D8A81427-3783-4B51-B181-42C34F652C10Q28586013-97F30279-56A3-49B0-A24C-3DE95820305FQ28586194-3D3B7F64-9B33-41FC-B015-F749B42D25B8Q28587801-16EABEEE-6B79-4555-84C7-5280664DFA68Q28588130-F474CF6C-8A2A-4E2F-AAF0-660B13D28B9BQ28591949-580A6B25-28CE-49E3-81FB-7B52AE014C04Q28593503-FF964BEE-75FE-4B98-99E1-8247372ED6EAQ28646257-DD8E6B6C-5AF6-4BA0-83BE-170671E8026AQ30450699-7F3B5B19-E657-4D0B-93FC-4CAA82D4EC73Q30480507-3F821B49-8FF4-41D0-8A98-BDD8809B2487Q33209762-37DB1AA7-A3D6-49CE-BC7E-789511B9BBA6Q33341337-506942D9-5DF4-413F-A13B-526A0115242CQ33410797-362C9C23-207E-42A3-81F7-AC0B77EB55B5Q33551454-673F8DBB-AA6F-4536-9DEB-76A405378436Q33555616-1A6DB8C6-7F5E-450B-A5BF-3A001D2BA506Q33577294-DD2D8F18-C882-457B-8143-C2A296A18D56Q33707186-78581DB0-07D2-4C76-BEA7-2777043011F1Q33826530-3A9EF46B-37AC-4207-A021-88B113ACE14EQ33906292-36F7BC9B-5760-4866-814A-CC2C5E87116BQ33976319-327DD710-3402-4222-A556-5755FE041B35Q34015442-768CD351-21D6-47AE-BC79-2113C3784A48Q34050919-77287064-2BD5-4C97-9B6E-5D5B70D60945
P2860
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Continuous expression of Cbfa1 ...... rescues Cbfa1-deficient mice.
@ast
Continuous expression of Cbfa1 ...... rescues Cbfa1-deficient mice.
@en
type
label
Continuous expression of Cbfa1 ...... rescues Cbfa1-deficient mice.
@ast
Continuous expression of Cbfa1 ...... rescues Cbfa1-deficient mice.
@en
prefLabel
Continuous expression of Cbfa1 ...... rescues Cbfa1-deficient mice.
@ast
Continuous expression of Cbfa1 ...... rescues Cbfa1-deficient mice.
@en
P2093
P2860
P356
P1433
P1476
Continuous expression of Cbfa1 ...... rescues Cbfa1-deficient mice.
@en
P2093
P2860
P304
P356
10.1101/GAD.845101
P577
2001-02-01T00:00:00Z