HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.
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Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrateThe G protein α chaperone Ric-8 as a potential therapeutic targetFunctional analysis of Hsp70 inhibitorsStructural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateRhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistanceDrug resistance in natural isolates of Leishmania donovani s.l. promastigotes is dependent of Pgp170 expressionHsp70-Bag3 interactions regulate cancer-related signaling networksHSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.A modified HSP70 inhibitor shows broad activity as an anticancer agent.Protein chaperones: a composition of matter review (2008 - 2013).Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide.Hsp70 clears misfolded kinases that partitioned into distinct quality-control compartments.Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer CellsMutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses.Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cellsHeat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.Cotranslational response to proteotoxic stress by elongation pausing of ribosomes.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cellsThe HSP70 family and cancerHistone deacetylase 10 promotes autophagy-mediated cell survival.HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice.Autophagy Modulation in Disease Therapy: Where Do We Stand?Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.Heat shock protein 70 - the next chaperone to target in the treatment of human acute myelogenous leukemia?Targeting the lysosome in cancer.Lysosomal Biology in Cancer.Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen.Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells.Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC).Differential roles of Hsp70 and Hsp90 in the assembly of the replicase complex of a positive-strand RNA plant virus.The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase.Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.
P2860
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P2860
HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
HSP70 inhibition by the small- ...... rance pathways in tumor cells.
@ast
HSP70 inhibition by the small- ...... rance pathways in tumor cells.
@en
type
label
HSP70 inhibition by the small- ...... rance pathways in tumor cells.
@ast
HSP70 inhibition by the small- ...... rance pathways in tumor cells.
@en
prefLabel
HSP70 inhibition by the small- ...... rance pathways in tumor cells.
@ast
HSP70 inhibition by the small- ...... rance pathways in tumor cells.
@en
P2093
P2860
P1476
HSP70 inhibition by the small- ...... rance pathways in tumor cells.
@en
P2093
Donna L George
J I-Ju Leu
Julia Pimkina
Maureen E Murphy
Pooja Pandey
P2860
P304
P356
10.1158/1541-7786.MCR-11-0019
P577
2011-06-02T00:00:00Z