HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. - Wikidata - wikimedia - TriplyDB

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

http://www.wikidata.org/entity/Q35118904

about

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate The G protein α chaperone Ric-8 as a potential therapeutic target Functional analysis of Hsp70 inhibitors Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance Drug resistance in natural isolates of Leishmania donovani s.l. promastigotes is dependent of Pgp170 expression Hsp70-Bag3 interactions regulate cancer-related signaling networks HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.A modified HSP70 inhibitor shows broad activity as an anticancer agent.Protein chaperones: a composition of matter review (2008 - 2013).Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide.Hsp70 clears misfolded kinases that partitioned into distinct quality-control compartments.Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses.Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.Cotranslational response to proteotoxic stress by elongation pausing of ribosomes.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells The HSP70 family and cancer Histone deacetylase 10 promotes autophagy-mediated cell survival.HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice.Autophagy Modulation in Disease Therapy: Where Do We Stand?Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.Heat shock protein 70 - the next chaperone to target in the treatment of human acute myelogenous leukemia?Targeting the lysosome in cancer.Lysosomal Biology in Cancer.Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70 HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen.Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells.Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC).Differential roles of Hsp70 and Hsp90 in the assembly of the replicase complex of a positive-strand RNA plant virus.The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase.Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.

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P2860

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

http://www.wikidata.org/entity/Q35118904

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年论文

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Molecular Cancer Research

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HSP70 inhibition by the small- ...... rance pathways in tumor cells.

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Donna L George

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J I-Ju Leu

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Julia Pimkina

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Maureen E Murphy

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Pooja Pandey

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

Hsp70 chaperones: cellular functions and molecular mechanism

Structural basis for sorting mechanism of p62 in selective autophagy

Autophagy in the Pathogenesis of Disease

Autophagy fights disease through cellular self-digestion

Targeting heat shock proteins in cancer

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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