The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10.
about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesCrystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombinationMammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repairHuman MUS81 complexes stimulate flap endonuclease 1Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cellsRNA interference inhibition of Mus81 reduces mitotic recombination in human cellsEme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cellsMus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiaeDNA end-directed and processive nuclease activities of the archaeal XPF enzyme.Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Nucleases in homologous recombination as targets for cancer therapyMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeMechanism and regulation of incisions during DNA interstrand cross-link repairCrystal structure of the Mus81-Eme1 complexGenome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.Esc4/Rtt107 and the control of recombination during replication.Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.Identification of nucleases and phosphatases by direct biochemical screen of the Saccharomyces cerevisiae proteome.Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeastYeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex.RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activitiesEfficient second strand cleavage during Holliday junction resolution by RuvC requires both increased junction flexibility and an exposed 5' phosphate.The role of AtMUS81 in interference-insensitive crossovers in A. thalianaEffects of mutations in SGS1 and in genes functionally related to SGS1 on inverted repeat-stimulated spontaneous unequal sister-chromatid exchange in yeastMUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.Chromosome-scale genetic mapping using a set of 16 conditionally stable Saccharomyces cerevisiae chromosomes.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma brucei.Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA associationPCNA and XPF cooperate to distort DNA substratesGEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.
P2860
Q24294687-5976F08A-8E43-4E39-85D1-A306BE7529A0Q24312821-2F95959B-13D3-4D15-9341-0E67532C276EQ24313650-10C6367D-C46D-40AF-994A-39A651F4FB5AQ24314301-4BDE42A3-7C1F-4DDE-A512-A679E36C8004Q24318451-C9324864-A66E-487D-B920-082B4D39814BQ24537482-D8B4BDB1-F93E-49D5-8C7A-04BD0AC675D2Q24627013-D32D7DCF-6367-4D78-8C89-74C1CF7C8C9BQ24644518-164EC7E1-A7D5-446C-8DA6-523B008E4DA6Q24684096-4DA567E6-C62D-4061-AE61-8F7A585A463DQ24814608-1F41CBE1-2E61-4D54-BC46-9F0A4FFCD82BQ25255738-264F7E32-66D4-49FA-BCD0-D0B723B4F320Q26822478-A85D7866-84D7-46BD-9AED-18C4B3D93036Q26864428-AE8109CB-CF8E-45B6-895D-F4125E66F5EFQ26865523-34B29076-0A24-49B7-AA2C-26CFD45FF701Q27650328-795370E1-C6B7-4EDC-BE4C-25C61A870968Q27929891-DF419D76-E690-45B5-B686-BF549F142CAEQ27931246-1F59A0E0-BB03-4AD3-AC15-1ADE8FF0CE51Q27932379-2B0FC99B-6A05-475B-B67D-00D48F2850A4Q27936167-2EA2316D-504B-4BAD-9C71-C40E99687BAEQ27937523-FD3582CE-6770-4C21-8ABE-B1757313FC53Q27938092-8762D1CA-A966-4408-A27C-D77EAFAC9D32Q27938156-58843135-C7C8-4F27-B907-A27CC8A0342AQ27938674-7975B40C-2AC3-4700-926D-1F0258A08D79Q27939265-34D8EE04-C536-4DB8-985F-3D3BE2A640E3Q27939352-68973605-2964-49D2-90CF-2AA6883F10D5Q27940191-09B67D00-2F8B-4F16-9092-3D864BEA9294Q27940287-F7266168-2231-4108-9928-1018ABF6A4BEQ28776095-98A9B785-83B5-48DC-BEEB-E31DDACD3FA2Q30862224-20D6683B-0EB0-4392-AEE2-ACAD071857CCQ33294063-510C4775-1D46-4388-B76E-3683C52F5D8FQ33312867-ADB68579-65CA-472A-AD83-F6B37F8C3F48Q33369076-30CD8596-602B-4147-822B-4D6D4B2622E1Q33373610-ECBCE485-B754-418E-AD32-4ACD35DB8A3DQ33604620-107BAD5A-23B3-4B10-9BB9-7B76AFF74268Q33632168-C37E96BB-5B55-4137-8109-3957631B4F0CQ33635502-CDFA1451-D505-46E7-8E33-0FEDA9C6D28CQ33698561-B15192F8-7407-415F-BE68-CE09853760D6Q33698685-97F55C85-1BE5-45ED-95AD-5DB9C233E6BEQ33719345-302EBB49-87ED-4F2A-B6A9-E01F3B3AE07EQ33737790-AD04428C-835E-4EC2-A442-3BAF48935031
P2860
The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The mechanism of Mus81-Mms4 cl ...... ogous endonuclease Rad1-Rad10.
@ast
The mechanism of Mus81-Mms4 cl ...... ogous endonuclease Rad1-Rad10.
@en
type
label
The mechanism of Mus81-Mms4 cl ...... ogous endonuclease Rad1-Rad10.
@ast
The mechanism of Mus81-Mms4 cl ...... ogous endonuclease Rad1-Rad10.
@en
prefLabel
The mechanism of Mus81-Mms4 cl ...... ogous endonuclease Rad1-Rad10.
@ast
The mechanism of Mus81-Mms4 cl ...... ogous endonuclease Rad1-Rad10.
@en
P2093
P2860
P1476
The mechanism of Mus81-Mms4 cl ...... ogous endonuclease Rad1-Rad10.
@en
P2093
Janet R Mullen
Steven J Brill
Suzanne A Bastin-Shanower
William M Fricke
P2860
P304
P356
10.1128/MCB.23.10.3487-3496.2003
P407
P577
2003-05-01T00:00:00Z