Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells
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Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesiclesArp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cellsUnconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cellsNexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.Push/pull mechanisms of GLUT4 traffic in muscle cells.Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid.Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle.Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.Identification of a role for CLASP2 in insulin action"Actin"g on GLUT4: membrane & cytoskeletal components of insulin action.Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues.Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate.In vivo imaging of GLUT4 translocation.Measuring GLUT4 translocation in mature muscle fibers.Odyssey between Scylla and Charybdis through storms of carbohydrate metabolism and diabetes: a career retrospective.Mapping insulin/GLUT4 circuitry.Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation.The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes.The CLASP2 Protein Interaction Network in Adipocytes Links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and Identifies SOGA1 as a Microtubule-Associated Protein.Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.A specific dileucine motif is required for the GGA-dependent entry of newly synthesized insulin-responsive aminopeptidase into the insulin-responsive compartment.Expression of constitutively active Akt/protein kinase B signals GLUT4 translocation in the absence of an intact actin cytoskeleton.Polymeric carrier-mediated intracellular delivery of phosphatidylinositol-3,4,5-trisphosphate to overcome insulin resistance.Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.Signaling cascade of insulin-induced stimulation of L-dopa uptake in renal proximal tubule cells.Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation.Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides.Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.
P2860
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P2860
Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
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2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Intracellular segregation of p ...... ng in L6 skeletal muscle cells
@ast
Intracellular segregation of p ...... ng in L6 skeletal muscle cells
@en
type
label
Intracellular segregation of p ...... ng in L6 skeletal muscle cells
@ast
Intracellular segregation of p ...... ng in L6 skeletal muscle cells
@en
prefLabel
Intracellular segregation of p ...... ng in L6 skeletal muscle cells
@ast
Intracellular segregation of p ...... ng in L6 skeletal muscle cells
@en
P2093
P2860
P1476
Intracellular segregation of p ...... ng in L6 skeletal muscle cells
@en
P2093
Nish Patel
Zayna A Khayat
P2860
P304
P356
10.1128/MCB.23.13.4611-4626.2003
P407
P577
2003-07-01T00:00:00Z