The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity.
about
Disentangling the many layers of eukaryotic transcriptional regulationContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyBipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of wingless signalingNew insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?Versatility of cooperative transcriptional activation: a thermodynamical modeling analysis for greater-than-additive and less-than-additive effectsA linear framework for time-scale separation in nonlinear biochemical systemsYeast-based assay identifies novel Shh/Gli target genes in vertebrate developmentModular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networksA theoretical framework for the regulation of Shh morphogen-controlled gene expressionNoise and information transmission in promoters with multiple internal States.A framework for modelling gene regulation which accommodates non-equilibrium mechanisms.Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity.Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networksIdentifying transcriptional cis-regulatory modules in animal genomes.Rapid evolutionary rewiring of a structurally constrained eye enhancer.The intersection of the extrinsic hedgehog and WNT/wingless signals with the intrinsic Hox code underpins branching pattern and tube shape diversity in the drosophila airways.Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors.Molecular and cellular mechanisms that initiate pain and itch.A Systematic Ensemble Approach to Thermodynamic Modeling of Gene Expression from Sequence Data.The Hedgehog pathway: role in cell differentiation, polarity and proliferationIn silico evolution of the Drosophila gap gene regulatory sequence under elevated mutational pressureA model of spatially restricted transcription in opposing gradients of activators and repressorsNeural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1.Massively parallel synthetic promoter assays reveal the in vivo effects of binding site variants.A Simple Grammar Defines Activating and Repressing cis-Regulatory Elements in PhotoreceptorsTime-scale separation--Michaelis and Menten's old idea, still bearing fruit.A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile.Transcriptional regulation of graded Hedgehog signalingIn pursuit of design principles of regulatory sequences.Spatiotemporal regulation of GLI target genes in the mammalian limb bud.Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution.Inhibition of the binding of MSG-intermolt-specific complex, MIC, to the sericin-1 gene promoter and sericin-1 gene expression by POU-M1/SGF-3.The cellular Ising model: a framework for phase transitions in multicellular environments.How to tune an enhancer.DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan.Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands.Mathematical models of morphogen gradients and their effects on gene expression.Beyond the balance of activator and repressor.
P2860
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P2860
The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The cis-regulatory logic of He ...... ompetition, and cooperativity.
@ast
The cis-regulatory logic of He ...... ompetition, and cooperativity.
@en
type
label
The cis-regulatory logic of He ...... ompetition, and cooperativity.
@ast
The cis-regulatory logic of He ...... ompetition, and cooperativity.
@en
prefLabel
The cis-regulatory logic of He ...... ompetition, and cooperativity.
@ast
The cis-regulatory logic of He ...... ompetition, and cooperativity.
@en
P2093
P2860
P1433
P1476
The cis-regulatory logic of He ...... ompetition, and cooperativity.
@en
P2093
Andrea I Ramos
Barak A Cohen
David S Parker
Michael A White
Scott Barolo
P2860
P356
10.1126/SCISIGNAL.2002077
P577
2011-06-07T00:00:00Z