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Membrane targeting of Rab GTPases is influenced by the prenylation motif

Membrane targeting of Rab GTPases is influenced by the prenylation motif

http://www.wikidata.org/entity/Q35153478

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Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts Rab1A is an mTORC1 activator and a colorectal oncogene Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor Refinement and prediction of protein prenylation motifs Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication Machinery Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases.Dual prenylation is required for Rab protein localization and function Bioinformatic and comparative localization of Rab proteins reveals functional insights into the uncharacterized GTPases Ypt10p and Ypt11p Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p.A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism Role of Rab GTPases in membrane traffic and cell physiology Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases.Rab13 Traffics on Vesicles Independent of Prenylation.Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders.Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.Regulation of mTORC1 by the Rab and Arf GTPases Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.Rab geranylgeranyl transferase β subunit is essential for male fertility and tip growth in Arabidopsis.The role of the small GTPase Rab31 in cancer.The Hsp90 chaperone complex regulates GDI-dependent Rab recycling Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators.Rab GTPases implicated in inherited and acquired disorders.Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.Targeting and localized signalling by small GTPases.Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.Chemical approaches to mapping the function of post-translational modifications.Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning.Exoenzyme S ADP-ribosylates Rab5 effector sites to uncouple intracellular trafficking.Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting.Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase.Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes.

P2860

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P2860

Membrane targeting of Rab GTPases is influenced by the prenylation motif

http://www.wikidata.org/entity/Q35153478

description

2003 nî lūn-bûn

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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Membrane targeting of Rab GTPases is influenced by the prenylation motif

@ast

Membrane targeting of Rab GTPases is influenced by the prenylation motif

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type

label

Membrane targeting of Rab GTPases is influenced by the prenylation motif

@ast

Membrane targeting of Rab GTPases is influenced by the prenylation motif

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prefLabel

Membrane targeting of Rab GTPases is influenced by the prenylation motif

@ast

Membrane targeting of Rab GTPases is influenced by the prenylation motif

@en

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MBC.E02-10-0639

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Molecular Biology of the Cell

P1476

Membrane targeting of Rab GTPases is influenced by the prenylation motif

@en

P2093

Richard F Godfrey

http://www.w3.org/2001/XMLSchema#string

P2860

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport

EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes

Rab27a is an essential component of melanosome receptor for myosin Va

Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice

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1882-1899

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scholarly article

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10.1091/MBC.E02-10-0639

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5

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14

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Miguel C. Seabra

Alistair N Hume

Jose S. Ramalho

Duarte C. Barral

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2003-02-06T00:00:00Z

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10712422

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12802062

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165084

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