about
Isoprenylcysteine carboxyl methyltransferase deficiency in miceRab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energyArmus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradationRab27a and Rab27b control different steps of the exosome secretion pathwayAre prenyl groups on proteins sticky fingers or greasy handles?Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5ADefective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type MaroteauxRapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.Rab and Arf proteins in genetic diseasesEvolution of the Rab family of small GTP-binding proteinsProtein prenyltransferasesRetinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cellsThe ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium.A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases.A general role for Rab27a in secretory cells.Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachmentPtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophilsHost PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Cloning, mapping and characterization of the human RAB27A gene.A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.Thousands of rab GTPases for the cell biologist.Rab GTPases, intracellular traffic and disease.Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium.Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.Deficient geranylgeranylation of Ram/Rab27 in choroideremia.Bacteria and protozoa differentially modulate the expression of Rab proteinsStructurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremiaImpaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.Membrane targeting of Rab GTPases is influenced by the prenylation motifThe melanosome as a model to study organelle motility in mammals.Rab27b regulates number and secretion of platelet dense granules.Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment.Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis.Rab27b regulates mast cell granule dynamics and secretion.Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Miguel C Seabra
@es
Miguel C Seabra
@nl
Miguel C Seabra
@sl
Miguel C. Seabra
@en
type
label
Miguel C Seabra
@es
Miguel C Seabra
@nl
Miguel C Seabra
@sl
Miguel C. Seabra
@en
prefLabel
Miguel C Seabra
@es
Miguel C Seabra
@nl
Miguel C Seabra
@sl
Miguel C. Seabra
@en
P1053
M-3280-2013
P106
P1153
7004369652
P21
P31
P3829
P496
0000-0002-6404-4892