Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
about
Normal human chromosomes have long G-rich telomeric overhangs at one endAccelerated epigenetic aging in Down syndromeTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationTelomere elongation in immortal human cells without detectable telomerase activitySpecific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patientsHuman telomerase contains evolutionarily conserved catalytic and structural subunitsThe telomere syndromesShort telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR miceExpression of p16(INK4a) in peripheral blood T-cells is a biomarker of human agingTelomeres shorten more slowly in long-lived birds and mammals than in short-lived onesRepair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts.T cell replicative senescence in human agingNucleotide shuffling and ssDNA recognition in Oxytricha nova telomere end-binding protein complexesFunctional requirement of p23 and Hsp90 in telomerase complexesShort Telomeres in Key Tissues Initiate Local and Systemic Aging in ZebrafishGenome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohortRace-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based SampleDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseMalignant transformation potentials of human umbilical cord mesenchymal stem cells both spontaneously and via 3-methycholanthrene inductionWRN loss induces switching of telomerase-independent mechanisms of telomere elongationExclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptasesTelomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.Telomere shortening is an in vivo marker of myocyte replication and aging.HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytesHuman papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoterTelomere shortening may be associated with human keloids.Kleemeier Award Lecture 2008--the canary in the coal mine: telomeres and human healthspan.Telomere biology in healthy aging and disease.miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζEffect of long-term hormone therapy on telomere length in postmenopausal women.RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cellsDefective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.Telomere length, aging, and somatic cell turnover.In vivo telomere dynamics of human hematopoietic stem cells.Human naive and memory T lymphocytes differ in telomeric length and replicative potential.Telomerase activity in normal and malignant hematopoietic cellsATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.Disease states associated with telomerase deficiency appear earlier in mice with short telomeresDifferences in the regulation of CD4 and CD8 T-cell clones during immune responses.Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts.
P2860
Q22065787-97DC9B0F-D98C-461A-B4EE-EADEDE8C367CQ22242648-066EF6B1-DBD2-4196-9A4B-F22B4B0DA846Q24310189-E15494E6-C4E4-4B36-A0CC-2578801C9DCDQ24598626-690B72B4-E3FF-47BF-B8AA-AA08E5BB2963Q24598792-C355C3A6-B22F-4392-82CE-0C1B0B7E9ADDQ24604009-AB6E75C4-EB06-458F-A4A8-00D623F7617DQ24632444-6D4C9396-3058-46BE-936A-9D49B207027EQ24633931-C72D0850-F1E7-4196-915D-27DEB4B7CF9BQ24646862-CAAC69CD-19AB-4510-BF1C-116BF8BFCF52Q24678913-D1D4B882-E675-4937-9DFC-68B82DF6040BQ24796117-1754F492-919E-4285-AD1B-020557CC3270Q27022690-8B056E2E-0A4A-490B-A364-12DD84EF7A94Q27641830-3465E026-DB18-4AF3-9C6D-C5D69294C26EQ28115669-27AFA859-3D68-42F4-AD53-081A307B3043Q28272305-28318AB7-56C6-4D5D-B553-44820DE49688Q28390712-3964D751-89D5-4140-9D9D-538ED61B26C8Q28392217-6745FE7F-3930-43A5-948E-0E3FFBED3E0DQ28511262-E65534F8-C58B-4E0A-BB4C-9D44921D20ABQ28536701-7E088B1B-4881-4EA3-BFC0-1DD1FBC4CAC5Q28542061-2737A517-2DCA-4B68-B6A7-392CAE6338B6Q28714820-42D9B419-1EF5-4BB2-829C-918269CBABC0Q30472352-1B804622-838E-4181-A949-FA0B9C587551Q30843774-3135CE37-A6EF-4DF2-87D7-2ECF77067B48Q31115332-5D288A25-20E6-4839-88AD-4D0D930B87A2Q33292282-D12A15A5-5007-4F5E-B12E-9539DE7ED2AFQ33513332-EFD57E60-E157-42CE-B34A-B9919AAAF562Q33567625-AEC3F1D5-5FC2-4545-A908-F9DB78977611Q33572237-881F6457-7141-4CBE-8F01-51F973D079F9Q33614271-6387CF28-294E-47AB-B2A2-5D3C9AC47647Q33628219-60735804-8CE1-4F3C-BD74-8016809B90FBQ33636343-BE49BDC7-C6B1-4719-B65A-2A3C6E4D0329Q33646411-730376BB-D9CF-44D0-BE7B-FD01CF0C3BF2Q33702690-F95AE0F5-E3E4-4417-89C8-BD687177F966Q33726870-EB871A0E-97BC-40DD-BDFE-35DE62257DD7Q33755629-A7F82467-BDAA-4846-AE10-ED7BDBF548C8Q33883794-BF90BD6A-1048-45FE-9A2D-E7B17CEB0E42Q33887607-D065130F-A302-4D06-B4B4-AFFF5074F6A0Q33890968-7F7AB33F-CD68-4553-AD05-9C3AB8B59AAFQ33905241-90E1108B-00D1-443F-8971-D21DECC43432Q33957590-64431795-01A1-4977-9946-9CCB51C83B87
P2860
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
description
1993 nî lūn-bûn
@nan
1993 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
@ast
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
@en
type
label
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
@ast
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
@en
prefLabel
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
@ast
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
@en
P2093
P2860
P1476
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
@en
P2093
C B Harley
F Schächter
P2860
P304
P407
P577
1993-04-01T00:00:00Z