Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro.
about
Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiaeEssential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cellsChromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisBinding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycleInvolvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatinATP bound to the origin recognition complex is important for preRC formationATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Localization of proteins bound to a replication origin of human DNA along the cell cycleReconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteinsMechanisms for initiating cellular DNA replicationThe B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formationIn the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.Identification of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cellsA subset of replication proteins enhances origin recognition and lytic replication by the Epstein-Barr virus ZEBRA protein.Redundant control of rereplication in fission yeast.Single molecule analysis of replicated DNA reveals the usage of multiple KSHV genome regions for latent replication.Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin.Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cellsEukaryotic MCM proteins: beyond replication initiation.Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopyStepwise assembly of initiation proteins at budding yeast replication origins in vitro.The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation.CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.Role for Cdk1 (Cdc2)/cyclin A in preventing the mammalian origin recognition complex's largest subunit (Orc1) from binding to chromatin during mitosisThe architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae.Archaeal eukaryote-like Orc1/Cdc6 initiators physically interact with DNA polymerase B1 and regulate its functionsDNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA bindingCdc6: a multi-functional molecular switch with critical role in carcinogenesisThe origin recognition complex in human diseases.Mechanisms and regulation of DNA replication initiation in eukaryotes.The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast.From structure to mechanism-understanding initiation of DNA replication.Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA.Site-specific interaction of the murine pre-replicative complex with origin DNA: assembly and disassembly during cell cycle transit and differentiation.The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.Inhibitory effects of acidic phospholipids on the binding of origin-recognition complex to origin DNA.Conserved hydrophobic amino acid residues in the N-terminal region of DnaA protein are involved in DnaA-DnaA interaction.Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.
P2860
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P2860
Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro.
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
Cdc6p modulates the structure ...... recognition complex in vitro.
@ast
Cdc6p modulates the structure ...... recognition complex in vitro.
@en
type
label
Cdc6p modulates the structure ...... recognition complex in vitro.
@ast
Cdc6p modulates the structure ...... recognition complex in vitro.
@en
prefLabel
Cdc6p modulates the structure ...... recognition complex in vitro.
@ast
Cdc6p modulates the structure ...... recognition complex in vitro.
@en
P2093
P2860
P1433
P1476
Cdc6p modulates the structure ...... recognition complex in vitro.
@en
P2093
B Stillman
N Takahashi
T Mizushima
P2860
P304
P577
2000-07-01T00:00:00Z