Adenovirus E1A targets key regulators of cell proliferation.
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Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsMolecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformationAdenovirus E1A proteins interact with the cellular YY1 transcription factorE2F-6, a member of the E2F family that can behave as a transcriptional repressorThe retinoblastoma protein binds to a family of E2F transcription factorsTransactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interactionReverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactionsDifferential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding proteinE2F-4 switches from p130 to p107 and pRB in response to cell cycle reentryAssociation of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcriptionAdenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activationMolecular basis for viral selective replication in cancer cells: activation of CDK2 by adenovirus-induced cyclin EE1A promotes association between p300 and pRB in multimeric complexes required for normal biological activityAdenovirus E1A243 disrupts the ATF/CREB-YY1 complex at the mouse c-fos promoter.Identification of a novel E1A response element in the mouse c-fos promoter.Role of baculovirus IE2 and its RING finger in cell cycle arrest.A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).Regulation of the human proliferating cell nuclear antigen promoter by the adenovirus E1A-associated protein p107Oncolytic adenovirus: preclinical and clinical studies in patients with human malignant gliomas.Experimental approaches for the treatment of malignant gliomas.The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation.Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiationSuppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function.Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP.The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.Oncogenicity of human papillomavirus- or adenovirus-transformed cells correlates with resistance to lysis by natural killer cells.Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisThe early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycleCharacterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes.DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins.E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmkE1a induces the expression of epithelial characteristics.Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and rasSuppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein.The adenovirus E1A repression domain disrupts the interaction between the TATA binding protein and the TATA box in a manner reversible by TFIIB.Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsMutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1.The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300
P2860
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P2860
Adenovirus E1A targets key regulators of cell proliferation.
description
1992 nî lūn-bûn
@nan
1992 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Adenovirus E1A targets key regulators of cell proliferation.
@ast
Adenovirus E1A targets key regulators of cell proliferation.
@en
type
label
Adenovirus E1A targets key regulators of cell proliferation.
@ast
Adenovirus E1A targets key regulators of cell proliferation.
@en
prefLabel
Adenovirus E1A targets key regulators of cell proliferation.
@ast
Adenovirus E1A targets key regulators of cell proliferation.
@en
P1433
P1476
Adenovirus E1A targets key regulators of cell proliferation.
@en
P2093
P304
P577
1992-01-01T00:00:00Z