Electrophysiology of stimulus-secretion coupling in human beta-cells.
about
Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells.Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretionInterleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1Statistical approaches and software for clustering islet cell functional heterogeneity.Beta-cell CaV channel regulation in physiology and pathophysiology.Unifying concepts in stimulus-secretion coupling in endocrine cells and some implications for therapeutics.Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channelsHigh-content screening identifies a role for Na(+) channels in insulin productionIs dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death.Detection of exocytosis at individual pancreatic beta cells by amperometry at a chemically modified microelectrode.Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances.Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cellsDiabetes and insulin secretion: whither KATP?Mathematical modeling of heterogeneous electrophysiological responses in human β-cellsCalcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release. Unmasking by decreasing a stable pool of adenine nucleotides in mouse isletsThe isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy.NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells.Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysisNitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage.Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression.Regulation of calcium in pancreatic α- and β-cells in health and disease.Mathematical models of electrical activity of the pancreatic β-cell: a physiological review.Microfluidic perfusion systems for secretion fingerprint analysis of pancreatic islets: applications, challenges and opportunities.Inwardly rectifying potassium channels influence Drosophila wing morphogenesis by regulating Dpp release.Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds.The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance.Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells.Unperturbed islet α-cell function examined in mouse pancreas tissue slices.Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation.A biophysical model of electrical activity in human β-cells.Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca2+ regulation prevail over changes in insulin content.Mibefradil reduces blood glucose concentration in db/db miceBcl-2 and Bcl-xL suppress glucose signaling in pancreatic β-cellsCa2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat.
P2860
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P2860
Electrophysiology of stimulus-secretion coupling in human beta-cells.
description
1992 nî lūn-bûn
@nan
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Electrophysiology of stimulus-secretion coupling in human beta-cells.
@ast
Electrophysiology of stimulus-secretion coupling in human beta-cells.
@en
type
label
Electrophysiology of stimulus-secretion coupling in human beta-cells.
@ast
Electrophysiology of stimulus-secretion coupling in human beta-cells.
@en
prefLabel
Electrophysiology of stimulus-secretion coupling in human beta-cells.
@ast
Electrophysiology of stimulus-secretion coupling in human beta-cells.
@en
P2093
P356
P1433
P1476
Electrophysiology of stimulus-secretion coupling in human beta-cells.
@en
P2093
P304
P356
10.2337/DIAB.41.10.1221
P407
P577
1992-10-01T00:00:00Z